{
  "abstract": "Objectives: To compare 12-month serologic responses to three benzathine penicillin G (BPG)-based regimens among people with HIV (PWH) and early syphilis. Methods: We retrospectively included syphilis episodes treated with BPG, BPG plus 7-day doxycycline (BPG/doxycycline), or BPG/doxycycline plus single-dose ceftriaxone during 2018-2024. Episodes with baseline rapid plasma reagin (RPR) titers <1:4 or exposure to other Treponema pallidum -active antibiotics were excluded. Serologic response was defined as a ≥ 4-fold RPR decline at 12 months. Intention-to-treat (ITT) with last-observation-carried-forward and per-protocol analyses were performed. Results: Among 1077 episodes in 762 PWH, 453 received BPG, 570 BPG/doxycycline, and 54 BPG/doxycycline/ceftriaxone. ITT response rates were 74.6%, 83.2%, and 88.9%, respectively ( P < 0.001); per-protocol rates were 74.4%, 83.4%, and 89.8% ( P < 0.001). Higher baseline RPR titers and doxycycline-containing regimens were independently associated with response. In analyses directly comparing BPG/doxycycline with and without ceftriaxone, adding ceftriaxone to BPG/doxycycline was not significantly associated with a higher serologic response. Conclusions: BPG/doxycycline was associated with a higher likelihood of 12-month serologic response. The incremental association of ceftriaxone remained uncertain because of the small number of ceftriaxone-treated episodes.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan",
    "Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan",
    "Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan; Department of Tropical Medicine and Parasitology, National Taiwan University College of Medicine, Taipei, Taiwan",
    "Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Medicine, National Taiwan University Cancer Center, Taipei, Taiwan",
    "Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan",
    "Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Tropical Medicine and Parasitology, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan; Corresponding author."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kai-Hsiang Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Hsin-Yun Sun"
    },
    {
      "affs": [
        1
      ],
      "name": "Kuan-Yin Lin"
    },
    {
      "affs": [
        1
      ],
      "name": "Yu-Shan Huang"
    },
    {
      "affs": [
        2
      ],
      "name": "Sung-Hsi Huang"
    },
    {
      "affs": [
        3
      ],
      "name": "Wang-Da Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Yi-Chia Huang"
    },
    {
      "affs": [
        4
      ],
      "name": "Tzong-Yow Wu"
    },
    {
      "affs": [
        1
      ],
      "name": "Yu-Chung Chuang"
    },
    {
      "affs": [
        1
      ],
      "name": "Aristine Cheng"
    },
    {
      "affs": [
        1
      ],
      "name": "Li-Hsin Su"
    },
    {
      "affs": [
        5
      ],
      "name": "Chien-Ching Hung"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fvb0se505mhb2.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ijid.2026.109069",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S1201971226007046",
  "id": "fvb0se505mhb2",
  "issns": [
    "1201-9712",
    "1878-3511"
  ],
  "landing_url": "https://doi.org/10.1016/j.ijid.2026.109069",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC109-216"
    ],
    [
      "openalex",
      "2737|Syphilis Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7206175372",
  "pdf_url": "https://www.ijidonline.com/article/S1201-9712(26)00704-6/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/fvb0se505mhb2.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:33Z",
      "native_id": "97399c99e1a14811bf5544424abea216",
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      "url": "https://doi.org/10.1016/j.ijid.2026.109069"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Syphilis Diagnosis and Treatment",
      "subfield": "physiology"
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  ],
  "title": "Comparative effectiveness of three benzathine penicillin G-based regimens in people with HIV who presented with early syphilis",
  "title_text": "Comparative effectiveness of three benzathine penicillin G-based regimens in people with HIV who presented with early syphilis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:33Z",
  "url": "https://research.draconitic.com/paper/fvb0se505mhb2",
  "venue": "International Journal of Infectious Diseases",
  "versions": []
}