{
  "abstract": "Background and Objective: D-dimer results differ across analytical platforms, which may affect their clinical interpretation. This study aimed to compare the analytical agreement and threshold-based classification of three routinely used D-dimer analyzers. Methods: Of 150 consecutive residual citrated plasma specimens, 81 patient specimens with valid results on the Sysmex CS-2500, Tokra Novae MTI, and VIDAS 3 analyzers were included. Agreement was assessed using the intraclass correlation coefficient, Passing-Bablok regression, Bland-Altman analysis, and classification concordance at the fixed (500 ng/mL FEU) and age-adjusted thresholds. VIDAS 3 served solely as the comparator method. Results: Overall agreement was moderate to good; however, the platforms were not fully interchangeable. Sysmex CS-2500 and VIDAS 3 showed the closest agreement, with no significant constant or proportional bias, whereas Tokra Novae MTI exhibited significant proportional bias. Mixed classification across the three analyzers occurred in 21/81 patients (25.9%) at the fixed threshold and in 18/81 patients (22.2%) at the age-adjusted thresholds. Conclusions: Clinically relevant inter-platform differences persisted despite acceptable average agreement. Therefore, D-dimer results should not be regarded as interchangeable across analyzers, particularly near clinical decision thresholds, and platform-specific verification remains essential.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medical Biochemistry, Faculty of Medicine, Atlas University, 34408 Istanbul, Türkiye.",
    "Department of Chemistry, Yildiz Technical University, 34220 Istanbul, Türkiye.",
    "Department of Biophysics, Faculty of Medicine, Kütahya Health Sciences University, 43100 Kütahya, Türkiye.",
    "Department of Biostatistics and Medical Informatics, Faculty of Medicine, Istanbul Atlas University, 34408 Istanbul, Türkiye."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Bağnu Dündar",
      "orcid": "0000-0003-1052-5911"
    },
    {
      "affs": [
        0
      ],
      "name": "Betül Özbek Kurtul",
      "orcid": "0000-0003-3355-7801"
    },
    {
      "affs": [
        1
      ],
      "name": "Beyzanur Badilli",
      "orcid": "0009-0000-0664-7276"
    },
    {
      "affs": [
        2
      ],
      "name": "Sevgi Koçyiğit Sevinç"
    },
    {
      "affs": [
        3
      ],
      "name": "Elif Ertaş",
      "orcid": "0000-0003-1827-4862"
    },
    {
      "affs": [
        0
      ],
      "name": "Asiye Gök Yurttaş",
      "orcid": "0000-0002-6424-7411"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fvc3vkgnhx6q6.bib",
  "cited_by": 0,
  "doi": "10.3390/diagnostics16193119",
  "fulltext_url": "https://europepmc.org/articles/PMC13664498",
  "id": "fvc3vkgnhx6q6",
  "issns": [
    "2075-4418"
  ],
  "landing_url": "https://europepmc.org/article/MED/42882274",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Clinical Laboratory Practices and Quality Control"
    ]
  ],
  "openalex": "W7214340231",
  "pdf_url": "https://europepmc.org/articles/PMC13664498?pdf=render",
  "pmcid": "PMC13664498",
  "pmid": "42882274",
  "published": "2026-09-25",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fvc3vkgnhx6q6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42882274",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42882274"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Clinical Laboratory Practices and Quality Control",
      "subfield": "physiology"
    }
  ],
  "title": "Method Comparison of Three Automated D-Dimer Assays.",
  "title_text": "Method Comparison of Three Automated D-Dimer Assays.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/fvc3vkgnhx6q6",
  "venue": "Diagnostics (Basel, Switzerland)",
  "versions": []
}