{
  "abstract": "DNA is an attractive medium for data storage. Enabling efficient random access is essential for the practical use of DNA-based memory. We present a strategy for random access based on the selective release of target DNA from a nanofiber mesh matrix. Messages encoded in sets of DNA sequences are encapsulated inside stimuli-responsive small unilamellar vesicles (SUVs), embedded in an electrospun water-resistant nanofiber mesh. The target sequences are selectively released using orthogonal pH-based triggers. The orthogonality of these triggers enables the preservation of the SUVs containing the non-selected DNA, which remains in the fiber mesh for subsequent retrieval. This work combines sequence-independent chemical addressing with physical compartmentalization and double-layered protection. It represents initial steps towards a PCR-independent molecular selection system for random access in water-resistant fibers with potential applications in DNA-based memory architectures.",
  "abstract_shown": true,
  "affiliations": [
    "CIC NanoGUNE BRTA Donostia-San Sebastián 20018 Spain",
    "University of the Basque Country, EHU Donostia-San Sebastián 20018 Spain",
    "IKERBASQUE, Basque Foundation for Science 48009 Bilbao Spain"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Jokin Yeregui-Elosua",
      "orcid": "0009-0005-6893-3186"
    },
    {
      "affs": [
        0
      ],
      "name": "Diana Soukarie",
      "orcid": "0000-0003-3276-8738"
    },
    {
      "affs": [
        0
      ],
      "name": "Cecilia Wetzl",
      "orcid": "0000-0002-5495-2141"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Alexander M. Bittner",
      "orcid": "0000-0003-4815-2444"
    },
    {
      "affs": [
        0
      ],
      "name": "Ibon Santiago",
      "orcid": "0000-0002-2822-9830"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fve3jzs2e5xba.bib",
  "cited_by": 0,
  "doi": "10.1039/d6na00595k",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13632630/",
  "id": "fve3jzs2e5xba",
  "issns": [
    "2516-0230"
  ],
  "landing_url": "https://doi.org/10.1039/d6na00595k",
  "language": "en",
  "licence": "CC-BY-3.0",
  "licence_label": "CC BY 3.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/3.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1312|DNA and Biological Computing"
    ]
  ],
  "openalex": "W7213869632",
  "pdf_url": "https://pubs.rsc.org/na/article-pdf/doi/10.1039/D6NA00595K/14737728/d6na00595k.pdf",
  "pmcid": "PMC13632630",
  "pmid": "42828351",
  "published": "2026-09-21",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/fve3jzs2e5xba.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:00Z",
      "native_id": "PMC13632630",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6na00595k"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|DNA and Biological Computing",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Stimuli-responsive vesicles in water-resistant nanofibers for molecular random access in DNA data storage",
  "title_text": "Stimuli-responsive vesicles in water-resistant nanofibers for molecular random access in DNA data storage",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:00Z",
  "url": "https://research.draconitic.com/paper/fve3jzs2e5xba",
  "venue": "Nanoscale Advances",
  "versions": []
}