{
  "abstract": "Gastrulation is thought to be driven primarily by forces generated within individual cells. These cell-intrinsic forces collectively induce tissue-scale flows and transform the monolayered embryo into a multilayered structure. However, as the embryo constitutes a mechanically closed system, these flows must be balanced by regions of resistance or anchoring to enable asymmetric morphogenesis. In the Drosophila embryo, integrin-mediated attachment of the blastoderm to the vitelline envelope has been shown to stabilize germ band extension at the organismal scale. Disrupting such an attachment leads to a characteristic twisting phenotype. Yet, how this attachment shapes concurrent global morphogenetic events remains unclear. We discovered that the integrin -subunit scab, which mediates the attachment, is expressed in three different regions of the cellular blastoderm near prominent invagination events. Through a combination of light-sheet imaging, genetic and mechanical perturbations, we demonstrate that integrin-enhanced friction is essential for unidirectional tissue flows in those regions, with effects including cephalic furrow positioning and epithelial stability. Guided by a minimal physical model, we further show that multiple attachment sites enhance the robustness and reproducibility of global tissue movements. Together, our results indicate that Drosophila gastrulation emerges from a balance between cell-intrinsic force generation and spatially distributed adhesion to the surrounding envelope, which together shape tissue flows at the embryo scale.",
  "abstract_shown": true,
  "affiliations": [
    "Max Planck Institute of Molecular Cell Biology and Genetics"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "M. B. Cuenca"
    },
    {
      "name": "W. Y. Yau"
    },
    {
      "name": "G. Serafini"
    },
    {
      "name": "Y. Kim"
    },
    {
      "name": "C. D. Modes"
    },
    {
      "affs": [
        0
      ],
      "name": "P. Tomancak"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fvh8rvb951q2d.bib",
  "cited_by": 1,
  "doi": "10.64898/2026.07.30.741527",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.07.30.741527v2.full",
  "id": "fvh8rvb951q2d",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.07.30.741527v2",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "developmental biology"
    ],
    [
      "openalex",
      "1307|Cellular Mechanics and Interactions"
    ]
  ],
  "openalex": "W7171823176",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.07.30.741527v2.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fvh8rvb951q2d.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:38Z",
      "native_id": "10.64898/2026.07.30.741527",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.07.30.741527v2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:developmental biology",
      "subfield": "developmental-biology"
    }
  ],
  "title": "Multiple contact sites between cells and the vitelline envelope coordinate tissue flows in Drosophila gastrulation",
  "title_text": "Multiple contact sites between cells and the vitelline envelope coordinate tissue flows in Drosophila gastrulation",
  "type": "preprint",
  "updated_at": "2026-10-30T12:22:38Z",
  "url": "https://research.draconitic.com/paper/fvh8rvb951q2d",
  "venue": "bioRxiv",
  "versions": []
}