{
  "abstract": "Embryonic hematopoiesis is thought to occur exclusively in the extraembryonic yolk sac before hematopoietic stem cells (HSCs) arise in the aorta–gonad–mesonephros region. Here we identify a previously unrecognized hematopoietic site at the maternal–fetal interface in mice, termed MIXER (Maternally Interfaced eXtraEmbRyonic) tissue, which develops contemporaneously with the yolk sac and exhibits robust hematopoietic activity. MIXER contains abundant hematopoietic precursors, including classical CSF1R+ erythro-myeloid progenitors and a unique embryonic CD4+CSF1R− Erythro-Myeloid PRogenitOR (eEMPROR) population. Lineage-tracing experiments demonstrate that eEMPROR cells contribute to select macrophage subpopulations during fetal development, primarily in the perivascular space. Notably, early human placental villi, before HSC emergence, also harbor CD4+ nucleated erythrocytes, indicating a conserved hematopoietic role for the maternal–fetal interface. These findings establish MIXER as an anatomically distinct niche for embryonic hematopoiesis and expand the developmental map of blood cell emergence in mammals.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Dermatology, Medical University of Vienna, Vienna, Austria",
    "Centenary Institute, Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales Australia",
    "Sydney Medical School, University of Sydney, Camperdown, New South Wales Australia",
    "Interfakultäres Institut für Biochemie (IFIB), Universität Tübingen, Tübingen, Germany",
    "Department of Obstetrics and Gynecology, Reproductive Biology Unit, Maternal–Fetal Immunology Group, Medical University of Vienna, Vienna, Austria",
    "Center for Pathophysiology, Infectiology and Immunology, Institute of Immunology, Medical University of Vienna, Vienna, Austria",
    "Medical Clinic III for Oncology, Hematology, Immuno-Oncology and Rheumatology, University Hospital Bonn, University of Bonn, Bonn, Germany",
    "Research Division of Infection Biology, Department of Medicine I, Medical University of Vienna, Vienna, Austria",
    "Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot, Israel",
    "School of Medical Sciences, University of Sydney, Sydney, New South Wales Australia",
    "University of Sydney Nano Institute, University of Sydney, Sydney, New South Wales Australia"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 21,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Rohit Jain",
      "orcid": "0000-0002-4905-462X"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Shweta Tikoo",
      "orcid": "0000-0001-5850-8075"
    },
    {
      "affs": [
        0
      ],
      "name": "Carlos Márquez-Burgoa",
      "orcid": "0009-0004-1433-6186"
    },
    {
      "affs": [
        0
      ],
      "name": "Stephanie A. Gerhofer",
      "orcid": "0009-0004-3944-3017"
    },
    {
      "affs": [
        1
      ],
      "name": "Brendon Martinez"
    },
    {
      "affs": [
        3
      ],
      "name": "Mariagiovanna Barresi",
      "orcid": "0000-0002-5297-8356"
    },
    {
      "affs": [
        0
      ],
      "name": "Dörte Symmank"
    },
    {
      "affs": [
        0
      ],
      "name": "Minoo Ghannadan"
    },
    {
      "affs": [
        4
      ],
      "name": "Barbara Öhler",
      "orcid": "0009-0008-2360-0670"
    },
    {
      "affs": [
        4
      ],
      "name": "Anna-Lena Höbler",
      "orcid": "0000-0001-5529-9378"
    },
    {
      "affs": [
        5
      ],
      "name": "Rafael de Freitas e Silva"
    },
    {
      "affs": [
        6
      ],
      "name": "Dirk Baumjohann",
      "orcid": "0000-0001-8385-8288"
    },
    {
      "affs": [
        3
      ],
      "name": "Susanne Feil"
    },
    {
      "affs": [
        3
      ],
      "name": "Robert Feil",
      "orcid": "0000-0002-7335-4841"
    },
    {
      "affs": [
        7
      ],
      "name": "Sylvia Knapp",
      "orcid": "0000-0001-9016-5244"
    },
    {
      "affs": [
        7
      ],
      "name": "Philipp Starkl",
      "orcid": "0000-0001-7521-129X"
    },
    {
      "affs": [
        5
      ],
      "name": "Wilfried Ellmeier",
      "orcid": "0000-0001-8192-8481"
    },
    {
      "affs": [
        8
      ],
      "name": "Steffen Jung",
      "orcid": "0000-0003-4290-5716"
    },
    {
      "affs": [
        4
      ],
      "name": "Jürgen Pollheimer"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Stuart T. Fraser"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Wolfgang Weninger",
      "orcid": "0000-0003-3133-8699"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fvty5yags7f6b.bib",
  "cited_by": 2,
  "doi": "10.1038/s41590-026-02683-4",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710174/",
  "id": "fvty5yags7f6b",
  "issns": [
    "1529-2908",
    "1529-2916"
  ],
  "landing_url": "https://doi.org/10.1038/s41590-026-02683-4",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2720|Hematopoietic Stem Cell Transplantation"
    ]
  ],
  "openalex": "W7223678205",
  "pdf_url": null,
  "pmcid": "PMC13710174",
  "pmid": "42934291",
  "published": "2026-10-26",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fvty5yags7f6b.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:11Z",
      "native_id": "PMC13710174",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41590-026-02683-4"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "journal-openalex:2403|T-cell and B-cell Immunology",
      "subfield": "immunology"
    }
  ],
  "title": "The maternal–fetal interface is an early hematopoietic niche enriched in distinct erythro-myeloid progenitors",
  "title_text": "The maternal–fetal interface is an early hematopoietic niche enriched in distinct erythro-myeloid progenitors",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:11Z",
  "url": "https://research.draconitic.com/paper/fvty5yags7f6b",
  "venue": "Nature Immunology",
  "versions": []
}