{
  "abstract": "DNA mimic foldamers (DMFOs) are helically folded aromatic oligoamides that mimic the shape and charge distribution of double-stranded B-DNA. DMFOs consist of an alternation of two amino acid monomers, M and Q. Here, we introduce a new synthetic approach of (MQ)n oligomers on solid phase that enabled the production of sequences as long as a 100mer, formally equivalent to a 50-base pair DNA duplex. The approach takes advantage of dimeric Fmoc-MQ-OH as building blocks. Three such macromonomers were synthesized using Q and M units bearing different side chains. Solid phase synthesis protocols were validated in all series. Helix handedness was shown to be determined by a single chiral residue. The purified long oligomers were analyzed by reversed phase HPLC, mass spectrometry, circular dichroism, and nuclear magnetic resonance spectroscopy for their purity, identity, and helix-handedness bias. Clusters of foldamers forming in the presence of Ca2+ could be visualized by cryogenic electron microscopy (cryo-EM). Lastly, a 72mer DMFO was shown to bind to the A-module of the chromatin remodeling complex INO80 slightly tighter than a comparable DNA duplex. A cryo-EM structure of the complex at a resolution of 3.59 Å showed that the DMFO occupies the A-module DNA binding region.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Manuel Loos"
    },
    {
      "name": "Franziska Därr"
    },
    {
      "name": "Céline Douat",
      "orcid": "0000-0003-2678-1048"
    },
    {
      "name": "Lisa Gourdon-Grünewaldt",
      "orcid": "0000-0003-0932-7838"
    },
    {
      "name": "Alberto López-Francos"
    },
    {
      "name": "Annika Brem"
    },
    {
      "name": "Karl-Peter Hopfner",
      "orcid": "0000-0002-4528-8357"
    },
    {
      "name": "Ivan Huc",
      "orcid": "0000-0001-7036-9696"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fvvvd9de7sxde.bib",
  "cited_by": 0,
  "doi": "10.1093/nar/gkag974",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13732123/",
  "id": "fvvvd9de7sxde",
  "issns": [
    "0305-1048",
    "1362-4962"
  ],
  "landing_url": "https://doi.org/10.1093/nar/gkag974",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "AcademicSubjects/SCI00010"
    ],
    [
      "heading",
      "Chemical Biology and Nucleic Acid Chemistry"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": "PMC13732123",
  "pmid": "42979756",
  "published": "2026-11-04",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/fvvvd9de7sxde.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:10Z",
      "native_id": "PMC13732123",
      "source": "pmc",
      "url": "https://doi.org/10.1093/nar/gkag974"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:0305-1048",
      "subfield": "molecular-biology"
    }
  ],
  "title": "DNA mimic helical foldamers with up to 100 units: synthesis and recognition of a multiprotein complex",
  "title_text": "DNA mimic helical foldamers with up to 100 units: synthesis and recognition of a multiprotein complex",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:10Z",
  "url": "https://research.draconitic.com/paper/fvvvd9de7sxde",
  "venue": "Nucleic Acids Research",
  "versions": []
}