{
  "abstract": "Heavy metal contamination poses a critical global health risk, affecting over 2.2 billion people and necessitating rapid, sensitive, and field-deployable detection technologies. Conventional analytical techniques such as ICP-MS and AAS, while highly accurate, remain constrained by high cost, complex instrumentation, and limited portability, restricting their use in decentralized monitoring. Quantum dots (QDs), owing to their size-tunable photoluminescence, high quantum yields, and excellent photostability, have emerged as powerful alternatives for ultrasensitive detection of toxic metal ions. This review provides a comprehensive and structured overview of QD-based sensing systems, beginning with fundamental aspects including synthesis strategies (colloidal, hydrothermal, and green routes), quantum confinement effects, and exciton dynamics governing optical behaviour. Emphasis is placed on surface functionalization approaches guided by Hard–Soft Acid–Base (HSAB) theory and chelation principles, enabling high selectivity toward target ions. Key sensing mechanisms, including fluorescence quenching and enhancement, Förster resonance energy transfer (FRET), and electrochemical transduction, are critically analyzed. Recent advances in hybrid nanostructures integrating QDs with graphene, metal–organic frameworks, and plasmonic materials are discussed, highlighting significant improvements in sensitivity down to picomolar levels and detection limits as low as 0.1 nM for priority contaminants such as Pb2+, Hg2+, Cd2+, As3+/5+, and Cr6+. In parallel, emerging eco-friendly alternatives, including carbon-based and heteroatom-doped QDs, are evaluated as sustainable substitutes to toxic Cd- and Pb-based systems, demonstrating competitive optical performance and improved biocompatibility. The review further examines practical considerations often overlooked, including matrix interference, reproducibility, long-term stability, and scalability. Strategies for translation from laboratory prototypes to real-world deployment are discussed, with focus on regulatory validation (IUPAC protocols, NIST standards), scalable manufacturing approaches, and cost-effective sensor design. Finally, future directions are outlined, emphasizing integration with artificial intelligence, IoT-enabled monitoring systems, and multiplexed sensing platforms aligned with ASSURED criteria. By bridging fundamental materials design with application-driven challenges, this work provides a roadmap for advancing QD-based sensors toward reliable, scalable, and commercially viable solutions for global heavy metal monitoring.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemical Engineering, Universitat Politècnica de Catalunya Barcelona Spain",
    "Dr Bansi Dhar Institute Gurugram Haryana India",
    "Department of Chemistry, School of Engineering and Technology, Manav Rachna International Institute of Research and Studies Faridabad Haryana-121004 India",
    "Biosensor Lab, Department of Chemistry, BITS Pilani KK Birla Goa Campus Vasco da Gama 403726 Goa India",
    "Department of Bioscience and Biotechnology, Banasthali Vidyapith Rajasthan 304022 India",
    "Computer Science & Engineering Department, Deenbandhu Chhotu Ram University of Science and Technology Sonipat 131039 India",
    "Department of Chemistry, MDU Rohtak-124001 Haryana India"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Garima Rathee",
      "orcid": "0000-0001-6825-3563"
    },
    {
      "affs": [
        2
      ],
      "name": "Sahil Kohli"
    },
    {
      "affs": [
        3
      ],
      "name": "Rida Hashami",
      "orcid": "0009-0009-6828-7574"
    },
    {
      "affs": [
        4
      ],
      "name": "Krati Singh"
    },
    {
      "affs": [
        5
      ],
      "name": "Jyotsna Rathee"
    },
    {
      "affs": [
        6
      ],
      "name": "Barkha Rathee",
      "orcid": "0000-0002-5283-0730"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Suphiya Khan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fw1en6yvmj601.bib",
  "cited_by": 0,
  "doi": "10.1039/d6ra06857j",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657092/?tool=EBI",
  "id": "fw1en6yvmj601",
  "issns": [
    "2046-2069"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13657092",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "2505|Quantum Dots Synthesis And Properties"
    ]
  ],
  "openalex": "W7221575094",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657092/pdf/?tool=EBI",
  "pmcid": "PMC13657092",
  "pmid": "42866199",
  "published": "2026-10-12",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/fw1en6yvmj601.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:29Z",
      "native_id": "PMC:PMC13657092",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13657092"
    },
    {
      "first_seen": "2026-11-01T12:23:36Z",
      "native_id": "PMC13657092",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6ra06857j"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Quantum Dots Synthesis And Properties",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Quantum dot sensors for heavy metal detection: from mechanistic design to field deployment: a review",
  "title_text": "Quantum dot sensors for heavy metal detection: from mechanistic design to field deployment: a review",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:20:50Z",
  "url": "https://research.draconitic.com/paper/fw1en6yvmj601",
  "venue": "RSC advances",
  "versions": []
}