{
  "abstract": "We found that right ventricular pressure overload from pulmonary hypertension significantly impairs left ventricular end-diastolic chamber stiffness. Gene therapy that attenuates progression of pulmonary hypertension also attenuated left ventricular chamber stiffening in a swine model. These findings suggest that adverse interventricular interactions may contribute to the worsening prognosis observed in patients with heart failure who develop pulmonary hypertension.",
  "abstract_shown": true,
  "affiliations": [
    "Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA",
    "Department of Medicine I, LMU University Hospital, Munich, Germany"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jernie Rideb"
    },
    {
      "affs": [
        0,
        1
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      "name": "Olympia Bikou"
    },
    {
      "affs": [
        0
      ],
      "name": "Kenji Watanabe"
    },
    {
      "affs": [
        0
      ],
      "name": "Renata Mazurek"
    },
    {
      "affs": [
        0
      ],
      "name": "Samta Veera"
    },
    {
      "affs": [
        0
      ],
      "name": "Jaume Aguero"
    },
    {
      "affs": [
        0
      ],
      "name": "Kiyotake Ishikawa"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fw9cb034vqa79.bib",
  "cited_by": 0,
  "doi": "10.1152/ajpheart.90090.2026",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13714864/",
  "id": "fw9cb034vqa79",
  "issns": [
    "0363-6135",
    "1522-1539"
  ],
  "landing_url": "https://doi.org/10.1152/ajpheart.90090.2026",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2740|Pulmonary Hypertension Research and Treatments"
    ]
  ],
  "openalex": "W7221052002",
  "pdf_url": null,
  "pmcid": "PMC13714864",
  "pmid": "42847198",
  "published": "2026-10-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fw9cb034vqa79.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:22:17Z",
      "native_id": "PMC13714864",
      "source": "pmc",
      "url": "https://doi.org/10.1152/ajpheart.90090.2026"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2705|Cardiac electrophysiology and arrhythmias",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Pulmonary Hypertension Increases Left Ventricular Chamber Stiffness Through Ventricular Interdependence and Is Attenuated by Pulmonary-Targeted SERCA2a Gene Therapy",
  "title_text": "Pulmonary Hypertension Increases Left Ventricular Chamber Stiffness Through Ventricular Interdependence and Is Attenuated by Pulmonary-Targeted SERCA2a Gene Therapy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:17Z",
  "url": "https://research.draconitic.com/paper/fw9cb034vqa79",
  "venue": "American journal of physiology. Heart and circulatory physiology",
  "versions": []
}