{
  "abstract": "Background\n\nUndergoing perioperative ischemia-reperfusion injury (I/RI), the prevalence of adverse cardiac events is high due to increased myocardial vulnerability in diabetic patients. However, the specific mechanisms of increased myocardial vulnerability in diabetes are still unknown.Objective\n\nTo investigate the specific mechanisms underlying increased myocardial vulnerability in diabetes and to explore potential myocardial protective strategies.Methods\n\nIn this study, we repeatedly verified through single-cell sequencing, fluorescence in situ staining, metabonomics, and animal experiments.Results\n\nHere we show for the first time that the cardiomyocyte subtype (C6 cardiomyocyte) is a cardiomyocyte characterized by myocardial contraction, and the reduction of its number and metabolic heterogeneity is the basis of myocardial ischemia-reperfusion injury in diabetes. Among them, TXNIP/PDK4 mediated metabolic reprogramming is an important reason for myocardial vulnerability in diabetes, and through regulating TXNIP/PDK4, we optimize myocardial energy metabolism. It can significantly improve the vulnerability of diabetes myocardium, play a good role in myocardial protection, and has clinical transformation potential.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Anesthesiology, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang, China.",
    "Catheterization Laboratory, Changji Prefecture People's Hospital, Changji Hui Autonomous Prefecture, Xinjiang, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zheng Zeng",
      "orcid": "0009-0001-5379-6933"
    },
    {
      "affs": [
        1
      ],
      "name": "Wei Shi"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuxuan He"
    },
    {
      "affs": [
        0
      ],
      "name": "Yue Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Cong Pu"
    },
    {
      "affs": [
        0
      ],
      "name": "Jingtong Tan"
    },
    {
      "affs": [
        0
      ],
      "name": "Hai Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "Haiping Ma"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fwdyaaqj0vss0.bib",
  "cited_by": 0,
  "doi": "10.1111/1753-0407.70277",
  "fulltext_url": "https://europepmc.org/articles/PMC13681344",
  "id": "fwdyaaqj0vss0",
  "issns": [
    "1753-0393",
    "1753-0407"
  ],
  "landing_url": "https://europepmc.org/article/MED/42899436",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2734|Cardiac Ischemia and Reperfusion"
    ]
  ],
  "openalex": "W7223001320",
  "pdf_url": "https://europepmc.org/articles/PMC13681344?pdf=render",
  "pmcid": "PMC13681344",
  "pmid": "42899436",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fwdyaaqj0vss0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42899436",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42899436"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2712|Diabetes, Cardiovascular Risks, and Lipoproteins",
      "subfield": "endocrinology-metabolism"
    }
  ],
  "title": "Txnip/PDK4-Mediated Hyperdependence on Fatty-Acid Oxidation Amplifies Susceptibility of Diabetic Myocardium to Ischemia-Reperfusion Damage.",
  "title_text": "Txnip/PDK4-Mediated Hyperdependence on Fatty-Acid Oxidation Amplifies Susceptibility of Diabetic Myocardium to Ischemia-Reperfusion Damage.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/fwdyaaqj0vss0",
  "venue": "Journal of diabetes",
  "versions": []
}