{
  "abstract": "A pink heart-shaped tablet, seized by law enforcement authorities, was found to contain a compound structurally related to 4-bromo-2,5-dimethoxyphenethylamine (2C-B), a new psychoactive substance (NPS). An extensive analytical investigation based on one- and two-dimensional nuclear magnetic resonance (NMR) experiments, combined with liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) and gas chromatography coupled to mass spectrometry (GC-MS) analyses, enabled the unambiguous identification of a new compound as 4-bromo-2,5-dimethoxyphenethyl tosylate, a putative synthetic intermediate in the synthesis of 2C-B. Finally, the targeted synthesis of the proposed structure provided independent confirmation of the correct structural assignment.",
  "abstract_shown": true,
  "affiliations": [
    "Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, 20133Milan, Italy.",
    "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122Milan, Italy.",
    "Dipartimento di Scienze della Salute, Università degli Studi di Milano, 20142Milan, Italy.",
    "Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, 20054Segrate, Italy.",
    "Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, 20133Milan, Italy.",
    "Gabinetto Regionale di Polizia Scientifica per la Lombardia, Polizia di Stato, Via Fatebenefratelli 11, 20121Milan, Italy.",
    "Institute for Molecular and Translational Cardiology (IMTC), San Donato Milanese, 20097Milan, Italy."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Sara Casati",
      "orcid": "0000-0002-5049-7321"
    },
    {
      "affs": [
        0
      ],
      "name": "Roberta F Bergamaschi"
    },
    {
      "affs": [
        2
      ],
      "name": "Michele Dei Cas"
    },
    {
      "affs": [
        0
      ],
      "name": "Alessandro Ravelli"
    },
    {
      "affs": [
        3
      ],
      "name": "Lea Sicuro"
    },
    {
      "affs": [
        4
      ],
      "name": "Gabriella Roda"
    },
    {
      "affs": [
        5
      ],
      "name": "Chiara Ciccarelli"
    },
    {
      "affs": [
        3
      ],
      "name": "Luca Mollica",
      "orcid": "0000-0001-5403-9507"
    },
    {
      "affs": [
        5
      ],
      "name": "Claudio Guidotti"
    },
    {
      "affs": [
        0
      ],
      "name": "Alessio Battistini"
    },
    {
      "affs": [
        0,
        6
      ],
      "name": "Paola Rota",
      "orcid": "0000-0001-5795-4989"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fwfpfn8zrvjcm.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.chemrestox.6c00170",
  "fulltext_url": "https://europepmc.org/articles/PMC13599472",
  "id": "fwfpfn8zrvjcm",
  "issns": [
    "0893-228X",
    "1520-5010"
  ],
  "landing_url": "https://europepmc.org/article/MED/42915732",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3005|Forensic Toxicology and Drug Analysis"
    ]
  ],
  "openalex": "W7204708470",
  "pdf_url": "https://europepmc.org/articles/PMC13599472?pdf=render",
  "pmcid": "PMC13599472",
  "pmid": "42915732",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fwfpfn8zrvjcm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:02Z",
      "native_id": "MED:42915732",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42915732"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3005|Forensic Toxicology and Drug Analysis",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Characterization of 4-Bromo-2,5-dimethoxyphenethyl Tosylate, a Synthetic Intermediate of 2C-B, Identified in a Seized Pink Heart-Shaped Tablet.",
  "title_text": "Characterization of 4-Bromo-2,5-dimethoxyphenethyl Tosylate, a Synthetic Intermediate of 2C-B, Identified in a Seized Pink Heart-Shaped Tablet.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:02Z",
  "url": "https://research.draconitic.com/paper/fwfpfn8zrvjcm",
  "venue": "Chemical research in toxicology",
  "versions": []
}