{
  "abstract": "Memory processing requires coordinated engagement of neuronal populations across brain networks and over time. How such coordination is organized in the human medial temporal lobe (MTL) remains unclear. Here, we show that MTL population activity is dynamically structured by a transient slow-oscillatory architecture that emerges during learning to promote offline consolidation and later recall. Using intracranial recordings that combine single-neuron spiking activity and local field potentials in human participants, we find that mnemonic engagement elicits on-demand slow-oscillatory bursts in the hippocampus. These hippocampal bursts synchronize gamma-band patterns across MTL regions, defining discrete coordination events that pace cross-regional coactivity motifs during learning. These learning-evoked population motifs are selectively reactivated during hippocampal ripples in post-learning rest, and the strength of their reactivation predicts subsequent recall accuracy. Together, these findings identify a multi-scale coordination mechanism that links distributed population activity across learning, consolidation, and recall in humans.",
  "abstract_shown": true,
  "affiliations": [
    "Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Medical Research Council Centre of Research Excellence in Restorative Neural Dynamics, Oxford, UK. Electronic address: adrien.causse@ndcn.ox.ac.uk",
    "CerCo, CNRS UMR5549, University of Toulouse, Toulouse, France; Brain Electrophysiology, Epilepsy and Sleep Unit, Neurology Department, Toulouse University Hospital, Toulouse, France",
    "Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Medical Research Council Centre of Research Excellence in Restorative Neural Dynamics, Oxford, UK",
    "Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK",
    "Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Medical Research Council Centre of Research Excellence in Restorative Neural Dynamics, Oxford, UK; Oxford Centre for Integrative Neuroimaging, University of Oxford, FMRIB, John Radcliffe Hospital, Oxford, UK",
    "CerCo, CNRS UMR5549, University of Toulouse, Toulouse, France",
    "Department of Neurology and Neurosurgery, Toulouse University Hospital, Toulouse, France; Toulouse Neuro Imaging Center, INSERM, U1214, Toulouse, France",
    "Centre de Neuro-Imagerie de Recherche, ICM Paris Brain Institute, Pitié-Salpêtrière Hospital, Paris, France",
    "Sorbonne Université, Paris Brain Institute, ICM, Inserm, CNRS, Pitié-Salpêtrière Hospital, Paris, France; Assistance Publique-Hôpitaux de Paris, Epilepsy and EEG Units and Reference Center of Rare Epilepsies, ERN EpiCare, Pitié-Salpêtrière Hospital, Paris, France",
    "CerCo, CNRS UMR5549, University of Toulouse, Toulouse, France. Electronic address: leila.reddy@cnrs.fr",
    "Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK; Medical Research Council Centre of Research Excellence in Restorative Neural Dynamics, Oxford, UK. Electronic address: david.dupret@bndu.ox.ac.uk"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Adrien A. Causse"
    },
    {
      "affs": [
        1
      ],
      "name": "Jonathan Curot",
      "orcid": "0000-0003-1494-8284"
    },
    {
      "affs": [
        2
      ],
      "name": "Vítor Lopes‐dos‐Santos",
      "orcid": "0000-0002-1858-0125"
    },
    {
      "affs": [
        3
      ],
      "name": "Raphael Nunes-da-Silva"
    },
    {
      "affs": [
        4
      ],
      "name": "Helen Catharine Barron",
      "orcid": "0000-0002-4575-6472"
    },
    {
      "affs": [
        5
      ],
      "name": "Vincent Dornier",
      "orcid": "0009-0007-9123-4716"
    },
    {
      "affs": [
        1
      ],
      "name": "Marie Denuelle",
      "orcid": "0000-0001-8692-1262"
    },
    {
      "affs": [
        6
      ],
      "name": "Amaury De Barros",
      "orcid": "0000-0001-9724-8616"
    },
    {
      "affs": [
        6
      ],
      "name": "Jean‐Christophe Sol"
    },
    {
      "affs": [
        6
      ],
      "name": "Jean-Albert Lotterie",
      "orcid": "0000-0003-4232-8533"
    },
    {
      "affs": [
        7
      ],
      "name": "Katia Lehongre",
      "orcid": "0000-0003-3531-9911"
    },
    {
      "affs": [
        7
      ],
      "name": "Sara Fernández-Vidal",
      "orcid": "0000-0001-5440-6020"
    },
    {
      "affs": [
        8
      ],
      "name": "Valério Frazzini",
      "orcid": "0000-0003-1187-3352"
    },
    {
      "affs": [
        8
      ],
      "name": "Vincent Navarro",
      "orcid": "0000-0003-0077-8114"
    },
    {
      "affs": [
        1
      ],
      "name": "Luc Valton",
      "orcid": "0000-0001-6718-8210"
    },
    {
      "affs": [
        5
      ],
      "name": "Emmanuel J. Barbeau",
      "orcid": "0000-0003-0836-3538"
    },
    {
      "affs": [
        2
      ],
      "name": "Timothy Denison",
      "orcid": "0000-0002-5404-4004"
    },
    {
      "affs": [
        9
      ],
      "name": "Leila Reddy",
      "orcid": "0000-0002-7078-1055"
    },
    {
      "affs": [
        10
      ],
      "name": "David Dupret",
      "orcid": "0000-0002-0040-1766"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fwqyxzmf89px9.bib",
  "cited_by": 5,
  "doi": "10.1016/j.neuron.2026.05.004",
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  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
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  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
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  "pmcid": "PMC7619154",
  "pmid": "42225066",
  "published": "2026-06-01",
  "publisher": "Elsevier",
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  "title": "A learning-evoked slow-oscillatory architecture paces population activity for offline reactivation across the human medial temporal lobe",
  "title_text": "A learning-evoked slow-oscillatory architecture paces population activity for offline reactivation across the human medial temporal lobe",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:14Z",
  "url": "https://research.draconitic.com/paper/fwqyxzmf89px9",
  "venue": "Neuron",
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