{
  "abstract": "Bacterial infection is a major cause that impedes wound healing. Conventional antibiotic-based treatments, while aimed at suppressing infections, often lead to the emergence of drug resistance. Furthermore, monotherapeutic strategies are frequently inadequate in managing the accompanying inflammation and oxidative stress that follow infection. This work developed chiral gold helical nanorods (AuHNRs)@CeO2 nanomaterials with photothermal bactericidal and reactive oxygen species (ROS) scavenging capabilities. D-AuHNRs@CeO2 exhibited chiral-selective bioactivity, which preferentially entered damaged L929 mouse fibroblasts cells under oxidative stress, scavenged intracellular ROS, and enhanced wound healing by upregulating Catalase (CAT), transforming growth factor-beta 1 (TGF-β1) in L929 cells, and matrix metalloproteinase-1 (MMP1) in human umbilical vein endothelial cells (HUVECs). Additionally, it effectively shifted RAW264.7 mouse macrophages from the pro-inflammatory M1 phenotype to the pro-repair M2 phenotype, fostering an anti-inflammatory, pro-repair immune microenvironment. Compared with L- and DL-counterparts, D-AuHNRs@CeO2 showed superior antibacterial and intracellular antioxidant performance. In a mouse model of infected wounds, D-AuHNRs@CeO2 markedly accelerated wound healing and reduced local bacterial burden, highlighting its multifunctional synergistic therapeutic potential. This work presents a novel nanoplatform for the effective management of infected wounds.\n\nStatement of significance: Wound healing is often hindered by a vicious cycle of bacterial infection, excessive inflammation, and oxidative stress. Here, chiral gold helical nanorods decorated with regenerative CeO2 (AuHNRs@CeO2) was developed. This platform leverages stereoselective interactions to enhance bacterial targeting, converts near-infrared light into heat for photothermal sterilization, and scavenges pathological reactive oxygen species to relieve oxidative stress and inflammation. By integrating multiple therapeutic modalities into one system, this work directly tackles the complex challenge of bacterial wound infection and the subsequent oxidative stress.",
  "abstract_shown": true,
  "affiliations": [
    "Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, Key Laboratory of Biomedical Analytics (Southwest University), Chongqing Science and Technology Bureau, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, PR China",
    "Key Laboratory of New Drug Screening from Traditional Chinese Medicine, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, PR China",
    "Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing, 400067, PR China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jinglei Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiusha Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Wen Kan"
    },
    {
      "affs": [
        0
      ],
      "name": "Wuyi Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Chen Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiuyue Liu"
    },
    {
      "affs": [
        2
      ],
      "name": "Jie Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Kaichuan Yan"
    },
    {
      "affs": [
        0
      ],
      "name": "Chengzhi Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jian Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fwvht1as73kqe.bib",
  "cited_by": 0,
  "doi": "10.1016/j.mtbio.2026.103754",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13698979/",
  "id": "fwvht1as73kqe",
  "issns": [
    "2590-0064"
  ],
  "landing_url": "https://doi.org/10.1016/j.mtbio.2026.103754",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Full Length Article"
    ],
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7222069581",
  "pdf_url": "https://europepmc.org/articles/PMC13698979?pdf=render",
  "pmcid": "PMC13698979",
  "pmid": "42936025",
  "published": "2026-10-15",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/fwvht1as73kqe.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:39Z",
      "native_id": "PMC13698979",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.mtbio.2026.103754"
    },
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42936025",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42936025"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Wound Healing and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Synergistic photothermal and antioxidant effects of chiral gold helical nanorods @CeO2 nanomaterials for accelerated infected wound healing",
  "title_text": "Synergistic photothermal and antioxidant effects of chiral gold helical nanorods @CeO2 nanomaterials for accelerated infected wound healing",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:35:36Z",
  "url": "https://research.draconitic.com/paper/fwvht1as73kqe",
  "venue": "Materials Today Bio",
  "versions": []
}