{
  "abstract": "Background: Postpartum hemorrhage (PPH) is a leading cause of maternal mortality, and women with repeat cesarean sections are at high risk. This study aimed to evaluate the efficacy of prophylactic tranexamic acid (TXA) in preventing PPH among women undergoing repeat cesarean sections.\n\nMethods: A retrospective cohort study was conducted including women with repeated cesarean sections at a tertiary obstetrical center in South China between July 2016 and December 2023. Patients were divided into the TXA group and the control group according to intraoperative prophylactic TXA administration. Given the imbalance in baseline characteristics, 1:2 propensity score matching (PSM) with a caliper of 0.01 was performed to balance confounding variables. The primary outcome was PPH incidence. Secondary outcomes included estimated blood loss, hemoglobin decline, additional uterotonic use, and blood transfusion rate.\n\nResults: After 1:2 PSM, 2,777 women in the TXA group were matched with 5,554 women in the control group, with baseline characteristics well balanced. The incidence of PPH was significantly lower in the TXA group than in the control group (11.09% vs. 17.03%, P < 0.001). The TXA group also demonstrated less calculated estimated blood loss, smaller hemoglobin reduction (12.06% vs. 18.44%, P < 0.001), and lower requirements for additional uterotonic agents (26.90% vs. 29.80%, P = 0.006). Multivariate logistic regression confirmed that prophylactic TXA was an independent protective factor against PPH (OR 0.620, 95% CI 0.540-0.712, P < 0.001). No significant difference was observed in blood transfusion rates (1.55% vs. 2.09%, P = 0.089).\n\nConclusion: Prophylactic TXA use was associated with a lower incidence of PPH and the need for additional uterotonics in women undergoing repeat cesarean sections. Randomized trials in this specific population are needed.",
  "abstract_shown": true,
  "affiliations": [
    "Guangzhou Women and Children’s Medical Center, Guangzhou Medical University , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiaodan Di"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaojun Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Zheng Zheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Lanlan Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "Taowei Dong"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiaozhu Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fwztq6txav626.bib",
  "cited_by": 0,
  "doi": "10.3389/fdsfr.2026.1911287",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13720946/?tool=EBI",
  "id": "fwztq6txav626",
  "issns": [
    "2674-0869"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13720946",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2735|Maternal and fetal healthcare"
    ]
  ],
  "openalex": "W7222623346",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13720946/pdf/?tool=EBI",
  "pmcid": "PMC13720946",
  "pmid": "42964985",
  "published": "2026-10-16",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/fwztq6txav626.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:36Z",
      "native_id": "PMC:PMC13720946",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13720946"
    },
    {
      "first_seen": "2026-11-03T12:21:44Z",
      "native_id": "PMC13720946",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fdsfr.2026.1911287"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2735|Maternal and fetal healthcare",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Efficacy of prophylactic tranexamic acid in preventing postpartum hemorrhage following repeat cesarean sections: a retrospective matched-cohort study",
  "title_text": "Efficacy of prophylactic tranexamic acid in preventing postpartum hemorrhage following repeat cesarean sections: a retrospective matched-cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:44Z",
  "url": "https://research.draconitic.com/paper/fwztq6txav626",
  "venue": "Frontiers in drug safety and regulation",
  "versions": []
}