{
  "abstract": "Background/Objectives: Palliative sedation may relieve refractory suffering in patients with advanced cancer receiving end-of-life care at home. We aimed to describe patient characteristics, palliative sedation use, refractory symptoms, and sedation-related outcomes in a specialized hospital-at-home unit. Methods: We conducted a retrospective observational study of patients with advanced cancer who died during 2022 while receiving care from the Instituto Valenciano de Oncología hospital-at-home unit, Spain. Admission required clinical and social assessment confirming the need for hospital-level home care, feasibility of care at home, and adequate caregiver support. Sociodemographic, clinical, and sedation-related data were obtained from medical records. Analyses were descriptive and exploratory; associations were unadjusted. Results: The cohort included 113 patients; 80 (70.8%) received palliative sedation. Median age was 76 years (IQR, 19), and 59 patients (52.2%) were men. An elastomeric infuser was used in 74 sedated patients (92.5%). Sedation duration had a median of 1 day (IQR, 2; range, 0–10). Symptom documentation was available for 56 sedated patients (70.0%); dyspnea was documented in 35 (62.5%), delirium in 19 (33.9%), and pain in 14 (25.0%). Symptoms could coexist. The median number of parenteral medications was 4 (IQR, 1). Conclusions: Palliative sedation was frequently used in this selected specialized home-care cohort and generally lasted a short period. The prevalence should not be generalized to other settings. Incomplete documentation and the retrospective, single-centre design limit interpretation. Prospective multi-centre studies are needed.",
  "abstract_shown": true,
  "affiliations": [
    "Grupo de Investigación en Cuidados Paliativos (GRICPAL), Facultad de Medicina y Ciencias de la Salud, Universidad Católica de Valencia “San Vicente Mártir”, c/Espartero 7, 46007 Valencia, Spain",
    "Fundación Instituto Valenciano de Oncología, c/Beltrán Báguena 4, 46009 Valencia, Spain"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Salvador Martín Utrilla",
      "orcid": "0000-0002-6166-5431"
    },
    {
      "affs": [
        0
      ],
      "name": "Paula Oliver de Haro"
    },
    {
      "affs": [
        0
      ],
      "name": "Julián Mollá Marinas"
    },
    {
      "affs": [
        1
      ],
      "name": "Antonio Mancheño Álvaro"
    },
    {
      "affs": [
        0
      ],
      "name": "Enrique Jesús Sáez Álvarez",
      "orcid": "0000-0001-9435-902X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fx74d2rrkfjxn.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218494",
  "fulltext_url": null,
  "id": "fx74d2rrkfjxn",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8494",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/fx74d2rrkfjxn.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:42Z",
      "native_id": "10.3390/jcm15218494",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8494"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Palliative Sedation at Home in Patients with Advanced Cancer: A Retrospective Observational Study of Clinical Characteristics and Sedation-Related Outcomes",
  "title_text": "Palliative Sedation at Home in Patients with Advanced Cancer: A Retrospective Observational Study of Clinical Characteristics and Sedation-Related Outcomes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T00:21:25Z",
  "url": "https://research.draconitic.com/paper/fx74d2rrkfjxn",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}