{
  "abstract": "Helicobacter pylori, a major cause of gastric ulcers and cancers, infects nearly half of the world’s population. The crystal structure of a potential H. pylori structure-guided drug-discovery target, tyrosine-tRNA synthetase (HpTyrRS), has been determined by the Seattle Structural Genomics Center for Infectious Disease (SSGCID). HpTyrRS is an enzyme that catalyzes the ATP-dependent attachment of tyrosine to tRNA. HpTyrRS was produced and crystallized, and its structure was determined at 2.2 Å resolution. HpTyrRS has a prototypical bacterial TyrRS topology and forms dimers in solution. HpTyrRS shares a conserved binding cavity for a previously identified Staphylococcus aureus TyrRS inhibitor (SB-219383). The reported structure and analysis establish HpTyrRS as a potential target for structure-guided drug discovery and repurposing.",
  "abstract_shown": true,
  "affiliations": [
    "Dartmouth College Hanover New Hampshire USA",
    "University of California, Berkeley, Berkeley, California, USA",
    "Center for Global Infectious Disease Research Seattle Children’s Research Institute 307 Westlake Avenue North, Suite 500 Seattle WA 98109 USA",
    "Seattle Structural Genomics Center for Infectious Diseases, Seattle, Washington, USA",
    "UCB BioSciences, Bainbridge Island, Washington, USA",
    "Chemistry and Biochemistry Hampton University Hampton VA 23666 USA",
    "Dartmouth Cancer Center, Lebanon, New Hampshire, USA",
    "Biochemistry and Cell Biology, Dartmouth Geisel School of Medicine, New Hampshire, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "David Igbalajobi",
      "orcid": "0009-0009-4172-1799"
    },
    {
      "affs": [
        0
      ],
      "name": "Jason E. Taylor"
    },
    {
      "affs": [
        1
      ],
      "name": "Raymond Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Jesuferanmi Ayanlade",
      "orcid": "0009-0009-7554-5084"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Rachael Zigweid",
      "orcid": "0000-0002-3932-7719"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Sandhya Subramanian",
      "orcid": "0000-0002-5853-7498"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Hannah Udell"
    },
    {
      "affs": [
        4
      ],
      "name": "Thomas E. Edwards",
      "orcid": "0000-0002-0474-8003"
    },
    {
      "affs": [
        4
      ],
      "name": "Jan Abendroth",
      "orcid": "0000-0002-8229-3243"
    },
    {
      "affs": [
        4
      ],
      "name": "Donald Lorimer",
      "orcid": "0000-0002-9638-8083"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Peter J. Myler",
      "orcid": "0000-0002-0056-0513"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Bart Staker",
      "orcid": "0000-0001-9570-5086"
    },
    {
      "affs": [
        5
      ],
      "name": "Edmund Moses Ndip"
    },
    {
      "affs": [
        3,
        6,
        7
      ],
      "name": "Oluwatoyin A. Asojo",
      "orcid": "0000-0002-4043-2700"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fx83ydevda0g2.bib",
  "cited_by": 0,
  "doi": "10.1107/s2053230x26010253",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13717830/",
  "id": "fx83ydevda0g2",
  "issns": [
    "2053-230X"
  ],
  "landing_url": "https://doi.org/10.1107/s2053230x26010253",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Early Career Research"
    ],
    [
      "openalex",
      "1312|RNA and protein synthesis mechanisms"
    ]
  ],
  "openalex": "W7223392337",
  "pdf_url": null,
  "pmcid": "PMC13717830",
  "pmid": "42924560",
  "published": "2026-10-23",
  "publisher": "International Union of Crystallography",
  "ris": "https://research.draconitic.com/paper/fx83ydevda0g2.ris",
  "sources": [
    {
      "first_seen": "2026-11-02T12:22:05Z",
      "native_id": "PMC13717830",
      "source": "pmc",
      "url": "https://doi.org/10.1107/s2053230x26010253"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|RNA and protein synthesis mechanisms",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Crystal structure of tyrosine-tRNA synthetase from Helicobacter pylori G27",
  "title_text": "Crystal structure of tyrosine-tRNA synthetase from Helicobacter pylori G27",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:05Z",
  "url": "https://research.draconitic.com/paper/fx83ydevda0g2",
  "venue": "Acta Crystallographica Section F: Structural Biology Communications",
  "versions": []
}