{
  "abstract": "Background/Aim: Diabetic wounds are characterized by chronic inflammation, impaired angiogenesis, and abnormal extracellular matrix (ECM) remodeling, which contribute to delayed wound healing and non-healing ulcers. Because ECM degradation and impaired matrix repair are central features of diabetic wound pathology, we evaluated an ultra-fine micronized human acellular dermal matrix (UFM-hADM; mean particle size approximately 70 µm) as an injectable ECM scaffold for diabetic wound repair.\n\nMaterials and Methods: Public transcriptomic datasets from human diabetic foot ulcers were reanalyzed to assess ECM remodeling- and growth factor-related gene expression patterns and enriched wound repair-associated pathways. Full-thickness excisional wounds were then created on the dorsum of streptozotocin (STZ)-induced diabetic mice and treated with perilesional microinjections of UFM-hADM or saline. Wound closure was assessed by digital planimetry. Wound tissues were analyzed by histology, immunohistochemistry, and quantitative reverse transcription-polymerase chain reaction.\n\nResults: Human diabetic foot ulcer datasets showed increased expression of several matrix metalloproteinase family members, altered ECM- and growth factor-related transcripts, and enrichment of tissue remodeling-associated pathways. In STZ-induced diabetic mice, UFM-hADM significantly improved wound closure compared with saline treatment, with near-complete epithelial coverage and more organized granulation tissue by Day 10. UFM-hADM-treated wounds showed increased expression of Col1a1, Col3a1, Tgfb1, and Egf, whereas Mmp1 and Mmp3 expressions were reduced. Immunohistochemistry showed increased CD31-positive microvessel density and α-smooth muscle actin-positive myofibroblast staining.\n\nConclusion: Human diabetic foot ulcer transcriptomic profiles support ECM remodeling and growth factor-related signaling as disease-associated features of chronic diabetic wounds. UFM-hADM improved wound repair in STZ-induced diabetic mice, with increased angiogenesis, reduced MMP expression, altered ECM-related gene expression, and more organized granulation tissue formation. These findings support further evaluation of UFM-hADM as an injectable human-derived ECM scaffold for chronic diabetic wounds.",
  "abstract_shown": true,
  "affiliations": [
    "College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea",
    "Department of R&D, Hulux, Seongnam, Republic of Korea",
    "Kyung Hee University Medical Center, Chamjoeun Hospital, Gwangju, Republic of Korea",
    "Department of R&D, Live Cell Instrument Co. Ltd, Namyangju, South Korea"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "HAO JIN"
    },
    {
      "affs": [
        1
      ],
      "name": "BINNA SHIN"
    },
    {
      "affs": [
        1
      ],
      "name": "KEUN-WOO JANG"
    },
    {
      "affs": [
        1
      ],
      "name": "DASEUL KIM"
    },
    {
      "affs": [
        1
      ],
      "name": "SUBIN LEE"
    },
    {
      "affs": [
        2
      ],
      "name": "JIN YOUNG KIM"
    },
    {
      "affs": [
        3
      ],
      "name": "YONGJIN LEE"
    },
    {
      "affs": [
        0
      ],
      "name": "SANG-MYEONG LEE"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fxba4sggqdwwt.bib",
  "cited_by": 0,
  "doi": "10.21873/invivo.14491",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13723968/",
  "id": "fxba4sggqdwwt",
  "issns": [
    "0258-851X",
    "1791-7549"
  ],
  "landing_url": "https://doi.org/10.21873/invivo.14491",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7224302062",
  "pdf_url": "https://iv.iiarjournals.org/content/invivo/40/6/3477.full.pdf",
  "pmcid": "PMC13723968",
  "pmid": "42957233",
  "published": "2026-10-29",
  "publisher": "International Institute of Anticancer Research",
  "ris": "https://research.draconitic.com/paper/fxba4sggqdwwt.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:22:30Z",
      "native_id": "PMC13723968",
      "source": "pmc",
      "url": "https://doi.org/10.21873/invivo.14491"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Wound Healing and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Ultra-fine Micronized Human Acellular Dermal Matrix Promotes Diabetic Wound Healing in a Mouse Model",
  "title_text": "Ultra-fine Micronized Human Acellular Dermal Matrix Promotes Diabetic Wound Healing in a Mouse Model",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:41Z",
  "url": "https://research.draconitic.com/paper/fxba4sggqdwwt",
  "venue": "In Vivo",
  "versions": []
}