{
  "abstract": "Neurotensin receptor 1 (NTSR1) activation suppresses feeding and promotes weight loss but is limited by adverse effects associated with Gq signaling. SBI-553 is a {beta}-arrestin-biased allosteric modulator of NTSR1 that avoids these effects. We evaluated the effects of SBI-553 (5 or 12 mg/kg, i.p.) on food intake and body weight in lean and diet-induced obese mice. Neither dose altered metabolic parameters, locomotor activity, or wheel running. SBI-553 did not affect ad libitum feeding in lean mice; however, both doses acutely reduced high-fat diet intake in obese mice. While 5 mg/kg had no effect on hunger-induced feeding, 12 mg/kg suppressed refeeding in both chow- and high-fat-fed mice of both sexes and reduced weight regain in obese mice. These findings identify SBI-553 as a potential strategy for reducing food intake and supporting weight loss.",
  "abstract_shown": true,
  "affiliations": [
    "Michigan State University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "J. Ramirez-Virella"
    },
    {
      "name": "K. Black"
    },
    {
      "name": "N. F. Dennis"
    },
    {
      "name": "R. Bugescu"
    },
    {
      "name": "K. Thompson"
    },
    {
      "name": "S. H. Olsen"
    },
    {
      "name": "L. M. Slosky"
    },
    {
      "name": "Z. A. McElligott"
    },
    {
      "affs": [
        0
      ],
      "name": "G. M. Leinninger"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fxq0nbjdcj4dz.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.08.30.748142",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.08.30.748142v1.full",
  "id": "fxq0nbjdcj4dz",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.08.30.748142v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "physiology"
    ],
    [
      "openalex",
      "2807|Regulation of Appetite and Obesity"
    ]
  ],
  "openalex": "W7207632421",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.08.30.748142v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fxq0nbjdcj4dz.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:10Z",
      "native_id": "10.64898/2026.08.30.748142",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.08.30.748142v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "biorxiv:physiology",
      "subfield": "physiology"
    }
  ],
  "title": "Biased signaling via NtsR1 restrains food intake and weight gain in obese mice",
  "title_text": "Biased signaling via NtsR1 restrains food intake and weight gain in obese mice",
  "type": "preprint",
  "updated_at": "2026-10-30T12:19:10Z",
  "url": "https://research.draconitic.com/paper/fxq0nbjdcj4dz",
  "venue": "bioRxiv",
  "versions": []
}