{
  "abstract": "Cellulose nanofibrils (CNFs) and TEMPO-oxidized cellulose nanofibrils (TOCNFs) are hydrated, high-aspect-ratio biomaterials with tunable physicochemical properties, whereas human-derived extracellular matrix (ECM) hydrogels provide matrix-associated biochemical cues. In this study, CNF- and TOCNF-based hybrid scaffolds incorporating human ECM hydrogel components were developed and evaluated in vitro as platforms relevant to cutaneous wound repair. Hybrid formulations gelled at physiological temperature and exhibited formulation-dependent shear-thinning behavior, elastic properties, protein release/leaching profiles, and porous fibrillar microstructures. Selected formulations supported cell-associated metabolic activity of human dermal fibroblasts and adipose-derived stromal/stem cells under two-dimensional and three-dimensional culture conditions. Additional exploratory studies demonstrated qualitative compatibility with adipogenic culture and condition-dependent changes in wound-gap width. In the absence of in vivo validation and confirmatory biological assays, these findings are interpreted as proof-of-concept rather than evidence of wound-healing efficacy. Overall, the results demonstrate the feasibility of combining CNF or TOCNF structural networks with human-derived ECM hydrogels to generate hybrid scaffolds with wound-relevant material properties and preliminary cytocompatibility, supporting further mechanistic and preclinical evaluation.",
  "abstract_shown": true,
  "affiliations": [
    "United States Department of Agriculture, Agricultural Research Service, Southern Regional Research Center, New Orleans, LA 70124, USA",
    "Obatala Sciences Inc., New Orleans, LA 70148, USA"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Judson. V. Edwards"
    },
    {
      "affs": [
        0
      ],
      "name": "Nicolette T. Prevost",
      "orcid": "0009-0003-6158-5188"
    },
    {
      "affs": [
        1
      ],
      "name": "Haley Lassiter"
    },
    {
      "affs": [
        1
      ],
      "name": "Katie Hamel",
      "orcid": "0000-0001-5639-9776"
    },
    {
      "affs": [
        0
      ],
      "name": "Michael W. Easson"
    },
    {
      "affs": [
        0
      ],
      "name": "Jacobs H. Jordan",
      "orcid": "0000-0002-0238-3864"
    },
    {
      "affs": [
        1
      ],
      "name": "Emma Rogers"
    },
    {
      "affs": [
        1
      ],
      "name": "Jordan Robinson"
    },
    {
      "affs": [
        1
      ],
      "name": "Trivia Frazier"
    },
    {
      "affs": [
        1
      ],
      "name": "Cecilia G. Sanchez"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fxtbt4p6608h3.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27219650",
  "fulltext_url": null,
  "id": "fxtbt4p6608h3",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/21/9650",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2502|Advanced Cellulose Research Studies"
    ]
  ],
  "openalex": "W7224132864",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-28",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/fxtbt4p6608h3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:58Z",
      "native_id": "10.3390/ijms27219650",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/21/9650"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Advanced Cellulose Research Studies",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Development of Hydrogel-Cellulose Nanofiber Hybrid Scaffolds for Potential Cutaneous Wound-Healing Applications",
  "title_text": "Development of Hydrogel-Cellulose Nanofiber Hybrid Scaffolds for Potential Cutaneous Wound-Healing Applications",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:58Z",
  "url": "https://research.draconitic.com/paper/fxtbt4p6608h3",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}