{
  "abstract": "Yana Ma,1,2 Weijia Zhu,1,2 Hang Yuan,1 Ruican Nie,1,2 Wen Luo,1,2 Hongtao Hu11Department of Interventional Radiology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, 450008, People’s Republic of China; 2HNHC Key Laboratory of Radiation Oncology for Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, 450008, People’s Republic of ChinaCorrespondence: Hongtao Hu, Department of Interventional Radiology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, 450008, People’s Republic of China, Email huhongtaogy@163.comAbstract: Adenoid cystic carcinoma (ACC) is an indolent yet aggressive malignancy characterized by perineural invasion, local recurrence, and distant metastasis. Current clinical management, primarily surgical resection and postoperative radiotherapy, offers limited efficacy, and systemic therapies have yielded unsatisfactory outcomes for recurrent and metastatic ACC, largely due to its unique molecular drivers and a structurally and immunologically complex tumor microenvironment (TME). Nanoplatforms, with their tunable physicochemical properties, surface functionalization, and designable stimuli-responsive release capabilities, offer a promising strategy for overcoming the barriers that hinder the efficacy of conventional therapies, which is crucial for improving treatment outcomes. In this review, we first summarize the key pathogenic features of ACC and the critical TME components, including immunosuppressive landscape, aberrant vasculature, stroma, and neural niches. We then outline rational design of nanoparticle system suited for ACC, highlighting active targeting and responsive strategies. Finally, we highlight recent advances in nanoplatform-based ACC therapies, from enhanced chemotherapy, radiotherapy, and ablation, to emerging therapeutic mechanisms, such as ferroptosis, cuproptosis, and TME reprogramming via cGAS-STING activation. By bridging ACC pathobiology with nanomedicine engineering, this review aims to provide insights that may accelerate the development of comprehensive and personalized therapeutic approaches for this challenging disease.Keywords: adenoid cystic carcinoma, nanoparticles, molecular drivers, tumor microenvironment, personalized therapy",
  "abstract_shown": true,
  "affiliations": [
    "Department of Interventional Radiology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, 450008, People’s Republic of China",
    "HNHC Key Laboratory of Radiation Oncology for Henan Cancer Hospital, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, 450008, People’s Republic of China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
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        1
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      "name": "Yana Ma"
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    {
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        1
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      "name": "Weijia Zhu"
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    {
      "affs": [
        0
      ],
      "name": "Hang Yuan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ruican Nie"
    },
    {
      "affs": [
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        1
      ],
      "name": "Wen Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "Hongtao Hu",
      "orcid": "0000-0002-5432-4014"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fy3e3w60b59jf.bib",
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  "doi": "10.2147/ijn.s638880",
  "fulltext_url": "https://www.dovepress.com/nanoplatform-enhanced-therapies-for-adenoid-cystic-carcinoma-integrati-peer-reviewed-fulltext-article-IJN",
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    "1176-9114"
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  "language": "en",
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  "licence_label": "CC BY-NC 4.0",
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  "pdf_url": "https://www.dovepress.com/article/download/121582",
  "pmcid": "PMC13729878",
  "pmid": "42979196",
  "published": "2026-10-01",
  "publisher": "Dove Medical Press",
  "ris": "https://research.draconitic.com/paper/fy3e3w60b59jf.ris",
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      "first_seen": "2026-11-02T14:20:53Z",
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  "subjects": [
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      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
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  "title": "Nanoplatform-Enhanced Therapies for Adenoid Cystic Carcinoma: Integrating Pathobiology, Microenvironment Modulation, and Synergistic Treatment Strategies",
  "title_text": "Nanoplatform-Enhanced Therapies for Adenoid Cystic Carcinoma: Integrating Pathobiology, Microenvironment Modulation, and Synergistic Treatment Strategies",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:36Z",
  "url": "https://research.draconitic.com/paper/fy3e3w60b59jf",
  "venue": "International Journal of Nanomedicine",
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}