{
  "abstract": "Background: Chromophobe renal cell carcinoma (chRCC) represents a distinct histological subtype of kidney cancer. While typically characterized by an indolent clinical course, it presents significant management challenges in advanced or late-stage disease.\n\nMain body of the abstract: This review presents current evidence regarding chRCC histopathology, emerging biomarkers, and proposed grading systems. We comprehensively analyze the molecular landscape, highlighting TP53 and PTEN mutations alongside characteristic chromosomal losses, while evaluating the role of epigenetic modifications and the immune microenvironment. Crucially, the paper details the mechanisms through which mitochondrial dysfunction and metabolic reprogramming drive chRCC pathogenesis. By assessing contemporary clinical trials, this work underscores the necessity for novel therapeutic interventions and the collection of large-scale prospective data to address current gaps in treatment.\n\nConclusion: A precision oncology framework for chRCC should prioritize reproducible diagnosis, cautious biomarker validation, and prospective rare-tumor trials to refine risk stratification and management.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12967-026-08668-z.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pathology, Changhai Hospital, Naval Medical University, 168 Changhai Rd. Building 17, Room 708, Shanghai, 200433 China",
    "Department of Nephrology, Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433 China",
    "Department of Urology, Changhai Hospital, Naval Medical University, 168 Changhai Road, Shanghai, 200433 China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiwen Lei"
    },
    {
      "affs": [
        1
      ],
      "name": "Rui Dong"
    },
    {
      "affs": [
        0
      ],
      "name": "Lijuan Yin"
    },
    {
      "affs": [
        2
      ],
      "name": "Zhenjie Wu"
    },
    {
      "affs": [
        2
      ],
      "name": "Linhui Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Miaoxia He",
      "orcid": "0000-0001-5666-6889"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fy84jkzesnpbd.bib",
  "cited_by": 0,
  "doi": "10.1186/s12967-026-08668-z",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13700147/",
  "id": "fy84jkzesnpbd",
  "issns": [
    "1479-5876"
  ],
  "landing_url": "https://doi.org/10.1186/s12967-026-08668-z",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2740|Renal cell carcinoma treatment"
    ]
  ],
  "openalex": "W7171568179",
  "pdf_url": "https://europepmc.org/articles/PMC13700147?pdf=render",
  "pmcid": "PMC13700147",
  "pmid": "42928313",
  "published": "2026-07-28",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/fy84jkzesnpbd.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:38Z",
      "native_id": "PMC13700147",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12967-026-08668-z"
    },
    {
      "first_seen": "2026-10-30T12:21:20Z",
      "native_id": "MED:42928313",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928313"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Renal cell carcinoma treatment",
      "subfield": "general"
    }
  ],
  "title": "Chromophobe renal cell carcinoma: addressing the translational gap toward precision oncology for advanced disease",
  "title_text": "Chromophobe renal cell carcinoma: addressing the translational gap toward precision oncology for advanced disease",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:36:36Z",
  "url": "https://research.draconitic.com/paper/fy84jkzesnpbd",
  "venue": "Journal of Translational Medicine",
  "versions": []
}