{
  "abstract": "Leptin and visfatin are adipokines involved in metabolic regulation and fetal development, but their associations with maternal gestational diabetes mellitus and neonatal growth remain incompletely understood. This study investigated the relationships between umbilical cord blood leptin and visfatin concentrations, maternal GDM status, and neonatal anthropometric characteristics. Umbilical cord blood samples from 88 neonates were analyzed for leptin and visfatin concentrations using ELISA. Statistical analysis was performed using IBM SPSS Statistics v.32. Cord blood leptin concentration was significantly higher in neonates born to mothers with GDM than in those born to mothers without GDM (median [IQR]: 2.22 [1.09] vs. 1.50 [0.77] ng/mL; p = 0.002). Visfatin concentration was positively correlated with birth weight (r = 0.359, p < 0.01) and head circumference (r = 0.233, p = 0.029), and differed significantly across neonatal weight categories (p < 0.001). Post hoc analysis showed significant differences in visfatin concentrations between AGA and LGA neonates (adjusted p < 0.001) and between SGA and LGA neonates (adjusted p = 0.008). In multivariable regression analysis, the models explained 9.3% and 20.5% of the variability in leptin and visfatin concentrations, respectively. Umbilical cord blood leptin and visfatin concentrations were differentially associated with maternal metabolic status and neonatal growth characteristics. GDM status was independently associated with cord blood leptin concentration, whereas neonatal weight category was independently associated with visfatin concentration. These findings suggest that cord blood adipokine concentrations may reflect aspects of the intrauterine metabolic environment and fetal growth; however, their clinical significance and potential predictive value require confirmation in larger longitudinal studies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Obstetrics and Gynecology, Faculty of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece",
    "Genesis Athens-Thrace Medically Assisted Reproduction Unit, 68100 Alexandroupolis, Greece",
    "Endometriosis Center, University Hospitals of Bristol and Weston NHS Foundation Trust, Trust Headquarters, Bristol BS1 3NU, UK"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Maria Styliou"
    },
    {
      "affs": [
        1
      ],
      "name": "Angeliki Tiptiri-Kourpeti",
      "orcid": "0000-0003-4710-7123"
    },
    {
      "affs": [
        0
      ],
      "name": "Panagiotis Konstantaras"
    },
    {
      "affs": [
        0
      ],
      "name": "Panagiotis Tsikouras"
    },
    {
      "affs": [
        0
      ],
      "name": "Theopi Nalbanti"
    },
    {
      "affs": [
        0
      ],
      "name": "Nektaria Kritsotaki"
    },
    {
      "affs": [
        0
      ],
      "name": "Aggeliki Gerente"
    },
    {
      "affs": [
        2
      ],
      "name": "Konstantinos Nikolettos",
      "orcid": "0000-0001-8291-5375"
    },
    {
      "affs": [
        0
      ],
      "name": "Nikolaos Nikolettos"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fyrz3p617hwq0.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198843",
  "fulltext_url": "https://europepmc.org/articles/PMC13665405",
  "id": "fyrz3p617hwq0",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/19/8843",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2729|Gestational Diabetes Research and Management"
    ]
  ],
  "openalex": "W7220416675",
  "pdf_url": "https://europepmc.org/articles/PMC13665405?pdf=render",
  "pmcid": "PMC13665405",
  "pmid": "42884086",
  "published": "2026-10-03",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/fyrz3p617hwq0.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:55Z",
      "native_id": "10.3390/ijms27198843",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/19/8843"
    },
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42884086",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42884086"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2729|Gestational Diabetes Research and Management",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Exploring the Role of Umbilical Cord Blood Leptin and Visfatin in Fetal Growth: Associations with Gestational Diabetes Mellitus and Neonatal Anthropometric Measurements",
  "title_text": "Exploring the Role of Umbilical Cord Blood Leptin and Visfatin in Fetal Growth: Associations with Gestational Diabetes Mellitus and Neonatal Anthropometric Measurements",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/fyrz3p617hwq0",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}