{
  "abstract": "Metastatic colon cancer commonly exhibits resistance to ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation. However, the mechanisms linking metabolic regulation to ferroptosis during metastatic progression remain incompletely understood. Here, we identified fatty acid-binding protein 2 (FABP2) as a regulator associated with ferroptosis sensitivity and liver metastatic phenotypes in colon cancer. Multi-omics analyses of clinical specimens showed reduced FABP2 expression in advanced colon cancer, which was associated with metastatic progression and poor survival. Mechanistically, FABP2 interacted with β-catenin, altered its intracellular localization, and was associated with reduced β-catenin/TCF4-dependent transcription of glutathione peroxidase 4 (GPX4), a key regulator of ferroptosis resistance. FABP2 overexpression increased ferroptosis sensitivity, whereas FABP2 downregulation promoted GPX4-dependent ferroptosis evasion and metastatic phenotypes. Pharmacological inhibition of Wnt/β-catenin signaling or GPX4 activity partially attenuated the effects of FABP2 loss. Together, these findings identify FABP2 as a factor associated with ferroptosis regulation and metastatic progression in colon cancer, and provide additional insight into the interplay between lipid metabolism, Wnt/β-catenin signaling, and ferroptosis.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Colorectal Cancer Center, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.",
    "The Guizhou Provincial Key Laboratory of Digestive System Diseases, Guiyang, Guizhou Province, China.",
    "Department of Infectious Diseases, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.",
    "School of Clinical Medicine, Guizhou Medical University, Guiyang, China.",
    "Key Laboratory of Hepatobiliary and Pancreatic Diseases Treatment and Bioinformatics Research, Guizhou Medical University, Guiyang, China.",
    "Department of Hepatobiliary Surgery, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China.",
    "Department of Colorectal Cancer Center, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China. yunhuanzhen72@163.com.",
    "The Guizhou Provincial Key Laboratory of Digestive System Diseases, Guiyang, Guizhou Province, China. yunhuanzhen72@163.com.",
    "The Guizhou Provincial Key Laboratory of Digestive System Diseases, Guiyang, Guizhou Province, China. 398441927@qq.com.",
    "Key Laboratory of Hepatobiliary and Pancreatic Diseases Treatment and Bioinformatics Research, Guizhou Medical University, Guiyang, China. 398441927@qq.com.",
    "Department of Hepatobiliary Surgery, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China. 398441927@qq.com.",
    "The Guizhou Provincial Key Laboratory of Digestive System Diseases, Guiyang, Guizhou Province, China. lihaiyang@gmc.edu.cn.",
    "Key Laboratory of Hepatobiliary and Pancreatic Diseases Treatment and Bioinformatics Research, Guizhou Medical University, Guiyang, China. lihaiyang@gmc.edu.cn.",
    "Department of Hepatobiliary Surgery, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China. lihaiyang@gmc.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Long Wu",
      "orcid": "0000-0002-7004-9569"
    },
    {
      "affs": [
        2
      ],
      "name": "Huan Wu",
      "orcid": "0000-0002-2870-0872"
    },
    {
      "affs": [
        3
      ],
      "name": "Yu-Tong Zhou",
      "orcid": "0009-0001-9101-1957"
    },
    {
      "affs": [
        3
      ],
      "name": "Guang-Ling Ou",
      "orcid": "0009-0000-4915-6637"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Yong Sun"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Xiao-Yun Li"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Yun-Huan Zhen",
      "orcid": "0000-0003-0809-0621"
    },
    {
      "affs": [
        8,
        9,
        10
      ],
      "name": "Kun Cao",
      "orcid": "0009-0003-8964-5154"
    },
    {
      "affs": [
        11,
        12,
        13
      ],
      "name": "Hai-Yang Li",
      "orcid": "0009-0003-4572-1880"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fz0jz2s77ds5b.bib",
  "cited_by": 0,
  "doi": "10.1038/s41419-026-09161-7",
  "fulltext_url": "https://europepmc.org/articles/PMC13720062",
  "id": "fz0jz2s77ds5b",
  "issns": [
    "2041-4889"
  ],
  "landing_url": "https://europepmc.org/article/MED/42957643",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2740|Ferroptosis and cancer prognosis"
    ]
  ],
  "openalex": "W7172097633",
  "pdf_url": "https://europepmc.org/articles/PMC13720062?pdf=render",
  "pmcid": "PMC13720062",
  "pmid": "42957643",
  "published": "2026-08-01",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/fz0jz2s77ds5b.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:47Z",
      "native_id": "MED:42957643",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42957643"
    },
    {
      "first_seen": "2026-11-02T12:23:55Z",
      "native_id": "PMC13720062",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41419-026-09161-7"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Ferroptosis and cancer prognosis",
      "subfield": "general"
    }
  ],
  "title": "Fatty acid-binding protein 2 suppresses liver metastasis by cytoplasmic sequestration of β-catenin to enhance ferroptosis sensitivity in colon cancer.",
  "title_text": "Fatty acid-binding protein 2 suppresses liver metastasis by cytoplasmic sequestration of β-catenin to enhance ferroptosis sensitivity in colon cancer.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:01Z",
  "url": "https://research.draconitic.com/paper/fz0jz2s77ds5b",
  "venue": "Cell death & disease",
  "versions": []
}