{ "abstract": "Objective: To assess the impact of prolonged time to surgery on cancer‐specific mortality (CSM) in patients with pathological T stage (pT)1b–2 N0M0 renal cell carcinoma (RCC) treated with nephrectomy (either partial [PN] or radical [RN]). Within the Surveillance, Epidemiology and End Results (SEER) database (2004–2021), we tested the effect of time to surgery >3 vs ≤3 months on CSM in patients with pT1b‐2N0M0 RCC.\n\nPatients and Methods: Propensity score matching (PSM) and multivariable competing risks regression (CRR) were performed. Subgroup analyses stratified patients according to time to surgery interval (≤1 vs 1–3 months, ≤3 vs 3–6 months, ≤3 vs >6 months), histotype, and grade.\n\nResults: Of 16 322 patients with pT1b–2 RCC treated with nephrectomy, time to surgery >3 months was recorded in 3023 (18%) patients. These patients were older (median age 64 vs 62 years) and harboured a smaller proportion of pT2 patients (19% vs 30%). After one‐to‐one PSM, 3023 (100%) patients with a time to surgery >3 months exhibited a 60‐month CSM of 7.6% vs 5.9% in 3023 (23%) patients with a time to surgery ≤3 months. In CRR time to surgery >3 months independently predicted 1.3‐fold higher CSM (P = 0.02). Subgroup analyses revealed a dose–response effect, with a CSM increase in 1.3‐fold fashion when time to surgery was 3–6 months vs 1.6‐fold fashion when time to surgery was >6 months. The detrimental effect of time to surgery>3 months was consistent across all grades but was not evidenced among patients with a non‐clear cell RCC.\n\nConclusion: In patients with pT1b‐2N0M0 treated with either PN or RN, prolonged time from diagnosis to surgery was associated with higher CSM. This association was not observed among patients with non‐clear cell RCC.", "abstract_shown": true, "affiliations": [ "Cancer Prognostics and Health Outcomes Unit, Division of Urology University of Montréal Health Center Montréal Québec Canada", "Division of Urology, Department of Translational Medicine Maggiore della Carità Hospital, University of Eastern Piedmont Novara Italy", "Division of Urology, Department of Oncology University of Turin Turin Italy", "Department of Neurosciences, Science of Reproduction and Odontostomatology University of Naples Federico II Naples Italy", "Division of Experimental Oncology/Unit of Urology, URI, Urological Research Institute IRCCS San Raffaele Scientific Institute Milan Italy", "Vita‐Salute San Raffaele University Milan Italy", "Department of Urology, University Hospital Goethe University Frankfurt Frankfurt am Main Germany", "Department of Urology, IEO European Institute of Oncology IRCCS Milan Italy", "Università degli Studi di Milano Milan Italy", "Division of Urology IRCCS Azienda Ospedaliero‐universitaria di Bologna Bologna Italy", "Department of Urology, Comprehensive Cancer Center Medical University of Vienna Vienna Austria", "Department of Urology Weill Cornell Medical College New York NY USA", "Department of Urology University of Texas Southwestern Medical Center Dallas TX USA", "Hourani Center for Applied Scientific Research Al‐Ahliyya Amman University Amman Jordan" ], "article_type": "research article", "arxiv": null, "author_total": 18, "authors": [ { "affs": [ 0, 1, 2 ], "name": "Michele Nicolazzini", "orcid": "0009-0003-7773-5101" }, { "affs": [ 0, 3 ], "name": "Federico Polverino", "orcid": "0009-0007-6218-3761" }, { "affs": [ 0, 4, 5 ], "name": "Leonardo Quarta", "orcid": "0009-0008-9523-3400" }, { "affs": [ 0, 6 ], "name": "Maximilian Filzmayer", "orcid": "0009-0005-5715-9965" }, { "affs": [ 0, 7, 8 ], "name": "Michele Petix", "orcid": "0009-0009-2893-2196" }, { "affs": [ 0, 9 ], "name": "Calogero Catanzaro", "orcid": "0009-0004-6265-5288" }, { "affs": [ 0 ], "name": "Nick Lee", "orcid": "0000-0002-7166-0503" }, { "affs": [ 0 ], "name": "Jordan A. Goyal", "orcid": "0009-0006-4609-8981" }, { "affs": [ 3 ], "name": "Nicola Longo", "orcid": "0009-0009-3394-0596" }, { "affs": [ 4 ], "name": "Gennaro Musi" }, { "affs": [ 6 ], "name": "Felix K. H. Chun", "orcid": "0000-0001-8486-9536" }, { "affs": [ 7 ], "name": "Alberto Briganti" }, { "affs": [ 9 ], "name": "Riccardo Schiavina" }, { "affs": [ 10, 11, 12, 13 ], "name": "Shahrokh F. Shariat" }, { "affs": [ 1 ], "name": "Carlotta Palumbo", "orcid": "0000-0002-6165-5276" }, { "affs": [ 1 ], "name": "Alessandro Volpe", "orcid": "0000-0003-3377-3782" }, { "affs": [ 0 ], "name": "Fred Saad" }, { "affs": [ 0 ], "name": "Pierre I. Karakiewicz" } ], "bibtex": "https://research.draconitic.com/paper/fz1hff966dmpa.bib", "cited_by": 0, "doi": "10.1111/bju.70468", "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13741110/", "id": "fz1hff966dmpa", "issns": [ "1464-4096", "1464-410X" ], "landing_url": "https://doi.org/10.1111/bju.70468", "language": "en", "licence": "CC-BY-NC-4.0", "licence_label": "CC BY-NC 4.0", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "Original Article" ], [ "openalex", "2730|Renal cell carcinoma treatment" ] ], "openalex": "W7214792822", "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bju.70468", "pmcid": "PMC13741110", "pmid": "42808865", "published": "2026-09-29", "publisher": null, "ris": "https://research.draconitic.com/paper/fz1hff966dmpa.ris", "sources": [ { "first_seen": "2026-11-10T12:22:14Z", "native_id": "PMC13741110", "source": "pmc", "url": "https://doi.org/10.1111/bju.70468" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2730|Renal cell carcinoma treatment", "subfield": "oncology" } ], "title": "The effect of time to nephrectomy on cancer‐specific mortality in pathological T stage (pT)1b–2 renal cancer", "title_text": "The effect of time to nephrectomy on cancer‐specific mortality in pathological T stage (pT)1b–2 renal cancer", "type": "peer-reviewed", "updated_at": "2026-11-10T12:22:14Z", "url": "https://research.draconitic.com/paper/fz1hff966dmpa", "venue": "Bju International", "versions": [] }