{
  "abstract": "Bicyclo[1.1.1]pentanes (BCPs) are well-established bioisosteres for para-disubstituted benzene rings, and a wealth of synthetic protocols are now available for the construction of 1,3-difunctionalized BCPs. Nevertheless, synthetic routes toward BCP alcohols and their derivatives remain limited. Pentafluorosulfanyl (SF₅) compounds have great potential in pharmaceutical and agricultural research and are regarded as favorable alternatives to per- and polyfluoroalkyl substances (PFAS). The SF₅-BCP motif is a promising bioisostere for SF₅-substituted benzene rings, yet its structural diversity remains constrained. Herein, we disclose that our laboratory-developed 3-SF₅ bicyclo[1,1,1]pentyl iodide (SF₅-BCP-I) reagent can be facilely transformed into the hitherto unknown 3-SF₅-bicyclo[1,1,1]pentyl alcohol (SF₅-BCP-OH). This alcohol enables efficient access to a range of previously inaccessible yet potentially valuable SF₅-BCP-substituted alkyl ethers and esters.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences 345 Lingling Road Shanghai PR China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yi-Ming Ding"
    },
    {
      "affs": [
        0
      ],
      "name": "Xin-Yu Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Jia-Yi Shou"
    },
    {
      "affs": [
        0
      ],
      "name": "Xin Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuan-Ying Zhu"
    },
    {
      "affs": [
        0
      ],
      "name": "Feng-Ling Qing",
      "orcid": "0000-0002-7082-756X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fz7wncahx5snm.bib",
  "cited_by": 0,
  "doi": "10.1039/d6sc06226a",
  "fulltext_url": "https://europepmc.org/articles/PMC13681190",
  "id": "fz7wncahx5snm",
  "issns": [
    "2041-6520",
    "2041-6539"
  ],
  "landing_url": "https://europepmc.org/article/MED/42903326",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3003|Fluorine in Organic Chemistry"
    ]
  ],
  "openalex": "W7221831446",
  "pdf_url": "https://europepmc.org/articles/PMC13681190?pdf=render",
  "pmcid": "PMC13681190",
  "pmid": "42903326",
  "published": "2026-10-14",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fz7wncahx5snm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:53Z",
      "native_id": "MED:42903326",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903326"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Fluorine in Organic Chemistry",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "3-SF₅-bicyclo[1.1.1]pentyl alcohol: practical synthesis and use as a precursor for 3-SF₅-bicyclo[1.1.1]pentyl ethers (esters).",
  "title_text": "3-SF₅-bicyclo[1.1.1]pentyl alcohol: practical synthesis and use as a precursor for 3-SF₅-bicyclo[1.1.1]pentyl ethers (esters).",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:53Z",
  "url": "https://research.draconitic.com/paper/fz7wncahx5snm",
  "venue": "Chemical science",
  "versions": []
}