{
  "abstract": "Due to the assumed plasticity of the immature brain, early-life brain alterations are thought to lead to better recoveries in comparison to the mature brain. Despite clinical needs, how neuronal networks and associated behaviors are affected by early-life brain stresses, such as pediatric concussions, have been overlooked. Here we provide first evidence in male mice that a single early-life concussion durably increases neuronal activity in the somatosensory cortex into adulthood, disrupting neuronal integration while the animal is performing sensory-related tasks. This represents a clinically relevant mechanism that was previously unappreciated for understanding impairment of sensory-related behavior performance. We also demonstrate that pharmacological modulation of the endocannabinoid system a year post-concussion is well-suited to rescue neuronal activity and plasticity, and normalizes sensory-related behavioral performance. These findings identify persistent alterations in cortical sensory processing following early-life concussion and demonstrate that neuronal and behavioral deficits remain amenable to pharmacological intervention long after injury.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Jérôme BADAUT",
      "orcid": "0000-0001-8475-0519"
    },
    {
      "name": "Lea HIPPAUF"
    },
    {
      "name": "Mathilde MALINCONI"
    },
    {
      "name": "Brenda P. NOARBE"
    },
    {
      "name": "Andre OBENAUS"
    },
    {
      "name": "Christophe J. DUBOIS",
      "orcid": "0000-0001-8307-8337"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fzhce2845f9ja.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-77767-8",
  "fulltext_url": null,
  "id": "fzhce2845f9ja",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://www.nature.com/articles/s41467-026-77767-8",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "1.sdv.mhep"
    ],
    [
      "hal",
      "1.sdv.neu"
    ],
    [
      "hal",
      "2.sdv.neu.nb"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://hal.science/hal-05855286/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-03",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/fzhce2845f9ja.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T09:20:20Z",
      "native_id": "10.1038/s41467-026-77767-8",
      "source": "feed-nature",
      "url": "https://www.nature.com/articles/s41467-026-77767-8"
    },
    {
      "first_seen": "2026-11-04T12:20:46Z",
      "native_id": "10.1038/s41467-026-77767-8",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41467-026-77767-8"
    },
    {
      "first_seen": "2026-11-07T12:20:26Z",
      "native_id": "hal-05855286",
      "source": "hal",
      "url": "https://hal.science/hal-05855286v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "hal:1.sdv.neu",
      "subfield": "neuroscience"
    },
    {
      "field": "medicine",
      "origin": "hal:1.sdv.mhep",
      "subfield": "general"
    }
  ],
  "title": "Endocannabinoid-mediated rescue of somatosensory cortex activity, plasticity and related behaviors following an early-life concussion in male mice",
  "title_text": "Endocannabinoid-mediated rescue of somatosensory cortex activity, plasticity and related behaviors following an early-life concussion in male mice",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:20:26Z",
  "url": "https://research.draconitic.com/paper/fzhce2845f9ja",
  "venue": "Nature Communications",
  "versions": []
}