{
  "abstract": null,
  "abstract_shown": false,
  "affiliations": [
    "Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA",
    "University of Michigan–Ann Arbor",
    "Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA",
    "Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA",
    "Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA",
    "Biomedical Research Core Facilities Advanced Genomics Core, University of Michigan, Ann Arbor, MI, USA",
    "Center for Individualized and Genomic Medicine Research, Department of Internal Medicine, Henry Ford Health, Detroit, MI, USA",
    "Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA",
    "South Texas Diabetes and Obesity Research Institute, School of Medicine, University of Texas, Rio Grande Valley, TX, USA",
    "Department of Medicine/Diabetes, UT Health San Antonio, San Antonio, TX, USA",
    "Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA",
    "Department of Cellular and Integrative Physiology, UT Health San Antonio, San Antonio, TX, USA",
    "Wellbeing Services County of South Karelia, South Karelia, Finland",
    "Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland",
    "Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland",
    "Kuopio Research Institute of Exercise Medicine, Kuopio, Finland",
    "Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland",
    "Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland",
    "Department of Public Health, University of Helsinki, Helsinki, Finland",
    "Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia",
    "Department of Genetics, University of North Carolina, Chapel Hill, NC, USA",
    "Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland",
    "Minerva Foundation Institute for Medical Research, Helsinki, Finland",
    "University of Helsinki, Faculty of Medicine, Research Programs Unit, Clinical and Molecular Metabolism (CAMM), Helsinki, Finland",
    "Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. scjp@umich.edu",
    "Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA. scjp@umich.edu",
    "Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. scjp@umich.edu"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 36,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Arushi Varshney",
      "orcid": "0000-0001-9177-9707"
    },
    {
      "affs": [
        0
      ],
      "name": "Nandini Manickam",
      "orcid": "0000-0001-9809-9712"
    },
    {
      "affs": [
        0
      ],
      "name": "Peter Orchard",
      "orcid": "0000-0001-6097-1106"
    },
    {
      "affs": [
        0
      ],
      "name": "Adelaide Tovar"
    },
    {
      "affs": [
        2,
        0
      ],
      "name": "Christa Ventresca",
      "orcid": "0000-0001-7406-2579"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhenhao Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Fan Feng",
      "orcid": "0000-0002-5990-312X"
    },
    {
      "affs": [
        0
      ],
      "name": "Joseph Mears"
    },
    {
      "affs": [
        3
      ],
      "name": "Michael R. Erdos",
      "orcid": "0000-0002-6603-1833"
    },
    {
      "affs": [
        3
      ],
      "name": "Narisu Narisu",
      "orcid": "0000-0002-8483-1156"
    },
    {
      "affs": [
        0
      ],
      "name": "Kirsten Nishino"
    },
    {
      "affs": [
        0
      ],
      "name": "Vivek Rai"
    },
    {
      "affs": [
        4
      ],
      "name": "Heather M. Stringham",
      "orcid": "0000-0002-2991-6392"
    },
    {
      "affs": [
        4
      ],
      "name": "Anne U. Jackson",
      "orcid": "0000-0002-9672-2547"
    },
    {
      "affs": [
        5
      ],
      "name": "Tricia Tamsen"
    },
    {
      "affs": [
        0
      ],
      "name": "Chao Gao",
      "orcid": "0000-0002-9316-2185"
    },
    {
      "affs": [
        6
      ],
      "name": "Mao Yang"
    },
    {
      "affs": [
        5
      ],
      "name": "Olivia I. Koues"
    },
    {
      "affs": [
        0
      ],
      "name": "Joshua D. Welch",
      "orcid": "0000-0002-5869-2391"
    },
    {
      "affs": [
        7
      ],
      "name": "Charles F. Burant"
    },
    {
      "affs": [
        6
      ],
      "name": "L. Keoki Williams"
    },
    {
      "affs": [
        8
      ],
      "name": "Chris Jenkinson"
    },
    {
      "affs": [
        9
      ],
      "name": "Ralph A. DeFronzo",
      "orcid": "0000-0003-3839-1724"
    },
    {
      "affs": [
        10,
        11,
        9
      ],
      "name": "Luke Norton"
    },
    {
      "affs": [
        12
      ],
      "name": "Jouko Saramies"
    },
    {
      "affs": [
        13,
        14,
        15
      ],
      "name": "Timo A. Lakka",
      "orcid": "0000-0002-9199-2871"
    },
    {
      "affs": [
        16
      ],
      "name": "Markku Laakso",
      "orcid": "0000-0002-3394-7749"
    },
    {
      "affs": [
        17,
        18,
        19
      ],
      "name": "Jaakko Tuomilehto"
    },
    {
      "affs": [
        20
      ],
      "name": "Karen L. Mohlke",
      "orcid": "0000-0001-6721-153X"
    },
    {
      "affs": [
        2,
        0
      ],
      "name": "Jacob O. Kitzman",
      "orcid": "0000-0002-6145-882X"
    },
    {
      "affs": [
        21,
        17,
        22,
        23
      ],
      "name": "Heikki A. Koistinen",
      "orcid": "0000-0001-7870-070X"
    },
    {
      "affs": [
        0
      ],
      "name": "Jie Liu"
    },
    {
      "affs": [
        4
      ],
      "name": "Michael Boehnke",
      "orcid": "0000-0002-6442-7754"
    },
    {
      "affs": [
        3
      ],
      "name": "Francis S. Collins",
      "orcid": "0000-0002-1023-7410"
    },
    {
      "affs": [
        4
      ],
      "name": "Laura J. Scott",
      "orcid": "0000-0002-4886-5084"
    },
    {
      "affs": [
        24,
        25,
        26
      ],
      "name": "Stephen C. J. Parker",
      "orcid": "0000-0001-8122-0117"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fznj0qsp0vr5d.bib",
  "cited_by": 22,
  "doi": "10.1038/s41588-026-02786-6",
  "fulltext_url": null,
  "id": "fznj0qsp0vr5d",
  "issns": [
    "1061-4036",
    "1546-1718"
  ],
  "landing_url": "https://doi.org/10.1101/2023.12.15.571696",
  "language": "en",
  "licence": "unknown",
  "licence_label": "Licence not stated",
  "licence_source": "unknown",
  "licence_url": null,
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Single-cell and spatial transcriptomics"
    ]
  ],
  "openalex": "W4393524305",
  "pdf_url": null,
  "pmcid": "PMC10760134",
  "pmid": "38168419",
  "published": "2026-10-28",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/fznj0qsp0vr5d.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T13:21:05Z",
      "native_id": "W4393524305",
      "source": "openalex",
      "url": "https://doi.org/10.1101/2023.12.15.571696"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Single-cell and spatial transcriptomics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Population-scale single-nucleus multi-omic profiling of skeletal muscle reveals extensive context-specific genetic regulation",
  "title_text": "Population-scale single-nucleus multi-omic profiling of skeletal muscle reveals extensive context-specific genetic regulation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:41Z",
  "url": "https://research.draconitic.com/paper/fznj0qsp0vr5d",
  "venue": "Nature Genetics",
  "versions": []
}