Genetics & genomics
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- PAD2 Deficiency Reveals Sex-Divergent Colonic Homeostasis, β-Catenin Remodeling, and Antibiotic-Sensitive Phenotypes
- Toward Advanced Quantitative Prediction of Missense Variant Effects
- EgKT2-1, an inwardly rectifying Shaker‑type potassium channel in oil palm that correlates with oil yield
- Decomposing population differences in type 2 diabetes through a high-resolution GWAS of ~600,000 individuals with East Asian ancestry
- Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress
- Tailoring capsid-directed evolution technology for improved AAV-mediated CAR-T generation
- AAVolve: Concatenated long-read deep sequencing enables whole capsid tracking during shuffled AAV library selection
- ADEVO: Proof-of-concept of adenovirus-directed EVOlution by random peptide display on the fiber knob
- Enhanced AAV transduction across preclinical CNS models: A comparative study in human brain organoids with cross-species evaluations
- Novel AAV variants with improved tropism for human Schwann cells
- In Search of Adeno-Associated Virus Vectors With Enhanced Cardiac Tropism for Gene Therapy
- Novel human liver-tropic AAV variants define transferable domains that markedly enhance the human tropism of AAV7 and AAV8
- Attenuation of Heparan Sulfate Proteoglycan Binding Enhances In Vivo Transduction of Human Primary Hepatocytes with AAV2
- Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening
- Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality
- Perceptions, knowledge, and attitudes toward genetics among psychiatric patients and their relatives: A systematic review and a meta-analysis
- Clinical utility of prenatal exome sequencing after normal chromosomal microarray in fetuses with structural anomalies
- Adaptive introgression between two Drosophila species enhances heat tolerance despite barriers to gene flow
- GeoEPred: A multimodal structure-aware geometric deep learning framework for Gram-negative bacterial secreted effector prediction with sequence semantics
- Immune markers mediate genetic relationships between immune diseases and psychiatric disorders
- A lethal ORC ATPase mutation is suppressed by alterations in ORC and RNA Pol II transcription components
- Chaperone protein DnaK-mediated regulation of spore coat assembly in Bacillus subtilis
- Oncolytic virus VT1092M synergizes with immune checkpoint inhibitors against intraperitoneal metastases of colorectal cancer
- The predictive value of machine learning for the response to anti-TNF-α therapy in patients with Crohn’s disease: a systematic review and meta-analysis
- Fresh ginseng-derived vesicle-like nanoparticles protect against intestinal barrier injury in inflammatory bowel disease via the miR-29a-5p/TLR4 axis