Longitudinal Trajectories of Antisynthetase Syndrome-associated Interstitial Lung Disease

Abstract

Objectives: Interstitial lung disease (ILD) is the principal determinant of morbidity and mortality in antisynthetase syndrome (ASyS). Data regarding ASyS-ILD trajectory phenotypes and factors influencing ILD clinical course remain scarce. We aimed to identify longitudinal ILD trajectories in patients with ASyS-ILD. Methods: A total of 92 patients with ASyS and ILD diagnosed by high-resolution computed tomography (HRCT), with forced vital capacity (FVC) measurement at ILD diagnosis and at least one additional measurement during follow-up, were included. Latent class mixed models (LCMMs) and linear mixed-effects models were performed to determine groups of patients with similar FVC trajectories and to identify risk factors associated with longitudinal FVC change. Results: The 3-class model demonstrated the best fit. Class 1 (n = 17) had intermediate baseline FVC but declined over time, with higher rates of ILD relapse, pulmonary hypertension, and chronic respiratory failure. Class 2 (n = 44) included younger patients with higher baseline FVC that remained stable during follow-up. Class 3 (n = 31) had lower baseline FVC and more rapidly progressive ILD at diagnosis but improved over time. In mixed-effects models, nonspecific interstitial pneumonia and organizing pneumonia patterns were associated with a more favorable longitudinal FVC trajectory (ˇ= 6.5; 95%CI, 1.8-11; P = .008 and ˇ= 7.7; 95%CI, 2.0-13; P = .009, respectively). Conclusions: We identified three phenotypes of ILD trajectories in patients with ASyS, including one group with declining FVC and poor respiratory prognosis. HRCT ILD pattern was the factor most predictive of longitudinal FVC change.

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BibTeX RIS

BibTeX

@article{billotte2026longitudinal,
  title = {{Longitudinal Trajectories of Antisynthetase Syndrome-associated Interstitial Lung Disease}},
  author = {Maxime Billotte and Houda Camara and Alain Meyer and Thomas Moulinet and Loïs Bolko and Kévin Didier and Sandra Dury and Bernard Bonnotte and Hervé Devilliers and Philippe Bonniaud and Guillaume Beltramo and Julien Campagne and Nadine Magy-Bertrand and Aurore Chaudier and Simon Valentin and Roland Jaussaud and Paul Decker},
  journal = {Archivos de bronconeumología},
  year = {2026},
  month = oct,
  doi = {10.1016/j.arbres.2026.05.015},
  url = {https://hal.univ-lorraine.fr/hal-05788226v1},
  note = {CC BY 4.0},
}

RIS

TY  - JOUR
TI  - Longitudinal Trajectories of Antisynthetase Syndrome-associated Interstitial Lung Disease
AU  - Maxime Billotte
AU  - Houda Camara
AU  - Alain Meyer
AU  - Thomas Moulinet
AU  - Loïs Bolko
AU  - Kévin Didier
AU  - Sandra Dury
AU  - Bernard Bonnotte
AU  - Hervé Devilliers
AU  - Philippe Bonniaud
AU  - Guillaume Beltramo
AU  - Julien Campagne
AU  - Nadine Magy-Bertrand
AU  - Aurore Chaudier
AU  - Simon Valentin
AU  - Roland Jaussaud
AU  - Paul Decker
PY  - 2026
DA  - 2026/10/09
JO  - Archivos de bronconeumología
DO  - 10.1016/j.arbres.2026.05.015
UR  - https://hal.univ-lorraine.fr/hal-05788226v1
AB  - Objectives: Interstitial lung disease (ILD) is the principal determinant of morbidity and mortality in antisynthetase syndrome (ASyS). Data regarding ASyS-ILD trajectory phenotypes and factors influencing ILD clinical course remain scarce. We aimed to identify longitudinal ILD trajectories in patients with ASyS-ILD. Methods: A total of 92 patients with ASyS and ILD diagnosed by high-resolution computed tomography (HRCT), with forced vital capacity (FVC) measurement at ILD diagnosis and at least one additional measurement during follow-up, were included. Latent class mixed models (LCMMs) and linear mixed-effects models were performed to determine groups of patients with similar FVC trajectories and to identify risk factors associated with longitudinal FVC change. Results: The 3-class model demonstrated the best fit. Class 1 (n = 17) had intermediate baseline FVC but declined over time, with higher rates of ILD relapse, pulmonary hypertension, and chronic respiratory failure. Class 2 (n = 44) included younger patients with higher baseline FVC that remained stable during follow-up. Class 3 (n = 31) had lower baseline FVC and more rapidly progressive ILD at diagnosis but improved over time. In mixed-effects models, nonspecific interstitial pneumonia and organizing pneumonia patterns were associated with a more favorable longitudinal FVC trajectory (ˇ= 6.5; 95%CI, 1.8-11; P = .008 and ˇ= 7.7; 95%CI, 2.0-13; P = .009, respectively). Conclusions: We identified three phenotypes of ILD trajectories in patients with ASyS, including one group with declining FVC and poor respiratory prognosis. HRCT ILD pattern was the factor most predictive of longitudinal FVC change.
SN  - 0300-2896
SN  - 1579-2129
ER  -

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