Directed Surface Immobilization of Coordination Cages for Host-Guest Studies.
- 1Analytical Chemistry - Biointerfaces, Ruhr University Bochum, Bochum44780, Germany.
- 2Department of Chemistry and Chemical Biology, TU Dortmund University, Dortmund44227, Germany.
- 3Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California94720, United States.
Abstract
Self-assembled coordination cages are bioinspired host-guest systems mimicking natural nanoconfinements and their functions as receptors and reaction compartments. While such systems are conventionally studied in solution or as bulk materials, the examination of surface-immobilized cages has recently emerged as an attractive approach. Here, we investigated the directed immobilization of bowl-shaped coordination cages [Pd2L3(MeCN)2]4+ on carboxy-terminated self-assembled monolayers. Spectroscopic ellipsometry and in situ flow experiments using SPR spectroscopy were used to characterize the immobilization of the coordination cages from the solution. ATR-FTIR confirmed the chemical identities of the surface-bound structures. Encapsulation of C60 in the coordination cages revealed faster surface absorption, consistent with an increase in binding affinity. Immobilized cages containing C60 guests were imaged by atomic force microscopy and revealed surface structures with dimensions consistent with those of the coordination cages, indicating successful capture on self-assembled monolayers.
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BibTeX
@article{muhringsalamone2026directed,
title = {{Directed Surface Immobilization of Coordination Cages for Host-Guest Studies.}},
author = {Samantha Muhring-Salamone and Lisa Schardt and Shota Hasegawa and Alexandre Walther and Björn Schmidt and Paul D Ashby and Guido H Clever and Axel Rosenhahn},
journal = {Langmuir : the ACS journal of surfaces and colloids},
year = {2026},
month = oct,
doi = {10.1021/acs.langmuir.6c03872},
url = {https://europepmc.org/article/MED/42918180},
note = {CC BY},
}
RIS
TY - JOUR
TI - Directed Surface Immobilization of Coordination Cages for Host-Guest Studies.
AU - Samantha Muhring-Salamone
AU - Lisa Schardt
AU - Shota Hasegawa
AU - Alexandre Walther
AU - Björn Schmidt
AU - Paul D Ashby
AU - Guido H Clever
AU - Axel Rosenhahn
PY - 2026
DA - 2026/10/01
JO - Langmuir : the ACS journal of surfaces and colloids
DO - 10.1021/acs.langmuir.6c03872
UR - https://europepmc.org/article/MED/42918180
AB - Self-assembled coordination cages are bioinspired host-guest systems mimicking natural nanoconfinements and their functions as receptors and reaction compartments. While such systems are conventionally studied in solution or as bulk materials, the examination of surface-immobilized cages has recently emerged as an attractive approach. Here, we investigated the directed immobilization of bowl-shaped coordination cages [Pd2L3(MeCN)2]4+ on carboxy-terminated self-assembled monolayers. Spectroscopic ellipsometry and in situ flow experiments using SPR spectroscopy were used to characterize the immobilization of the coordination cages from the solution. ATR-FTIR confirmed the chemical identities of the surface-bound structures. Encapsulation of C60 in the coordination cages revealed faster surface absorption, consistent with an increase in binding affinity. Immobilized cages containing C60 guests were imaged by atomic force microscopy and revealed surface structures with dimensions consistent with those of the coordination cages, indicating successful capture on self-assembled monolayers.
SN - 0743-7463
SN - 1520-5827
ER -