Early Patient-Reported Outcomes and Graft-Versus-Host Disease as Indicators of Long-Term Quality of Life and Fatigue After Allogeneic Hematopoietic Stem Cell Transplantation: A 24-Month Prospective Study
4 affiliations
- 1Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, 31-008 Krakow, Poland
- 2Department of Sport Didactics, Wroclaw University of Health and Sport Science, 51-612 Wroclaw, Poland
- 3Institute of Nursing and Midwifery, Faculty of Health Sciences, Jagiellonian University Medical College, 31-008 Krakow, Poland
- 4Chair of Hematology, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Krakow, Poland
Abstract
Background/Objectives: Long-term recovery after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is heterogeneous, and early patient-reported outcomes (PROs) may provide clinically relevant information about later survivorship. We examined whether quality of life (QoL), fatigue, and early graft-versus-host disease (GVHD) were associated with PROs at 24 months after allo-HSCT. Methods: Adult allo-HSCT recipients were prospectively followed at six predefined timepoints up to 24 months. The primary early landmark was 6 months (T3), and the primary long-term outcome was 24-month (T6) QoL assessed using the Functional Assessment of Cancer Therapy—Bone Marrow Transplant (FACT-BMT). Fatigue was assessed using the Brief Fatigue Inventory (BFI) and Functional Assessment of Chronic Illness Therapy—Fatigue (FACIT-F). Associations were examined using parsimonious regression models including early GVHD. Results: Twenty-eight participants had PRO data at both T3 and T6. Higher FACT-BMT at T3 was associated with higher FACT-BMT at T6 after adjustment for early GVHD (B = 1.077, 95% CI 1.019–1.135, p < 0.001). Early GVHD remained associated with lower T6 FACT-BMT (B = −6.133, 95% CI −9.373 to −2.893, p < 0.001). Higher BFI and lower FACIT-F at T3 were associated with poorer T6 QoL, while 6-month fatigue was also associated with corresponding 24-month fatigue outcomes. Among patients with GVHD, non-responders had less favorable 24-month fatigue outcomes than responders. Conclusions: PROs at 6 months were strongly associated with 24-month QoL and fatigue. The 6-month assessment may represent a clinically informative survivorship landmark, although larger multicenter studies are needed to confirm these associations.
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BibTeX
@article{lampart2026early,
title = {{Early Patient-Reported Outcomes and Graft-Versus-Host Disease as Indicators of Long-Term Quality of Life and Fatigue After Allogeneic Hematopoietic Stem Cell Transplantation: A 24-Month Prospective Study}},
author = {Gabriela Lampart and Sebastian Klich and Agnieszka Gniadek and Beata Piątkowska-Jakubas},
journal = {Cancers},
year = {2026},
month = nov,
doi = {10.3390/cancers18213542},
url = {https://www.mdpi.com/2072-6694/18/21/3542},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Early Patient-Reported Outcomes and Graft-Versus-Host Disease as Indicators of Long-Term Quality of Life and Fatigue After Allogeneic Hematopoietic Stem Cell Transplantation: A 24-Month Prospective Study
AU - Gabriela Lampart
AU - Sebastian Klich
AU - Agnieszka Gniadek
AU - Beata Piątkowska-Jakubas
PY - 2026
DA - 2026/11/04
JO - Cancers
DO - 10.3390/cancers18213542
UR - https://www.mdpi.com/2072-6694/18/21/3542
AB - Background/Objectives: Long-term recovery after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is heterogeneous, and early patient-reported outcomes (PROs) may provide clinically relevant information about later survivorship. We examined whether quality of life (QoL), fatigue, and early graft-versus-host disease (GVHD) were associated with PROs at 24 months after allo-HSCT. Methods: Adult allo-HSCT recipients were prospectively followed at six predefined timepoints up to 24 months. The primary early landmark was 6 months (T3), and the primary long-term outcome was 24-month (T6) QoL assessed using the Functional Assessment of Cancer Therapy—Bone Marrow Transplant (FACT-BMT). Fatigue was assessed using the Brief Fatigue Inventory (BFI) and Functional Assessment of Chronic Illness Therapy—Fatigue (FACIT-F). Associations were examined using parsimonious regression models including early GVHD. Results: Twenty-eight participants had PRO data at both T3 and T6. Higher FACT-BMT at T3 was associated with higher FACT-BMT at T6 after adjustment for early GVHD (B = 1.077, 95% CI 1.019–1.135, p < 0.001). Early GVHD remained associated with lower T6 FACT-BMT (B = −6.133, 95% CI −9.373 to −2.893, p < 0.001). Higher BFI and lower FACIT-F at T3 were associated with poorer T6 QoL, while 6-month fatigue was also associated with corresponding 24-month fatigue outcomes. Among patients with GVHD, non-responders had less favorable 24-month fatigue outcomes than responders. Conclusions: PROs at 6 months were strongly associated with 24-month QoL and fatigue. The 6-month assessment may represent a clinically informative survivorship landmark, although larger multicenter studies are needed to confirm these associations.
SN - 2072-6694
ER -