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Peer-reviewedCC BY-NC-NDnpj Biosensing

Organic electrochemical transistors for metabolite sensing across the transition from in vitro to in vivo

  • Jintao Zheng1,2
  • Xiaohong Jiang1,2
  • Jiacheng Yu1,2
  • Runzhi Zhou1,2
  • Haoyang Yan1,2
  • Zheng Liang1
  • Genquan Wu1
  • Keying Guo1,2,3,4
4 affiliations
  1. 1Department of Biotechnology and Food Engineering, Guangdong Technology Israel Institute of Technology (GTIIT), Shantou, China
  2. 2Faculty of Biotechnology and Food Engineering, Technion-Israel Institute of Technology (IIT), Haifa, Israel
  3. 3Guangdong Provincial Key Laboratory of Materials and Technologies for Energy Conversion, Guangdong Technion-Israel Institute of Technology (GTIIT), Shantou, China
  4. 4Monash Institute of Pharmaceutical Sciences (MIPS), Monash University, Parkville, VIC, Australia
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Abstract

Organic electrochemical transistors (OECTs) offer unparalleled signal amplification and biocompatibility for biomolecular sensing. This review systematically explores OECT principles, sensing mechanisms, and architectures, focusing on advancements in metabolite detection. We highlight how innovations in polymer materials and gate functionalization enhance in vitro detection performance. Crucially, we evaluate the emerging transition toward in vivo applications, addressing the technological hurdles of signal fidelity and tissue-device interfaces in complex biological systems.

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Cite

BibTeXRIS
BibTeX
@article{zheng2026organic,
  title = {{Organic electrochemical transistors for metabolite sensing across the transition from in vitro to in vivo}},
  author = {Jintao Zheng and Xiaohong Jiang and Jiacheng Yu and Runzhi Zhou and Haoyang Yan and Zheng Liang and Genquan Wu and Keying Guo},
  journal = {npj Biosensing},
  year = {2026},
  month = may,
  doi = {10.1038/s44328-026-00096-9},
  url = {https://doi.org/10.1038/s44328-026-00096-9},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Organic electrochemical transistors for metabolite sensing across the transition from in vitro to in vivo
AU  - Jintao Zheng
AU  - Xiaohong Jiang
AU  - Jiacheng Yu
AU  - Runzhi Zhou
AU  - Haoyang Yan
AU  - Zheng Liang
AU  - Genquan Wu
AU  - Keying Guo
PY  - 2026
DA  - 2026/05/22
JO  - npj Biosensing
DO  - 10.1038/s44328-026-00096-9
UR  - https://doi.org/10.1038/s44328-026-00096-9
AB  - Organic electrochemical transistors (OECTs) offer unparalleled signal amplification and biocompatibility for biomolecular sensing. This review systematically explores OECT principles, sensing mechanisms, and architectures, focusing on advancements in metabolite detection. We highlight how innovations in polymer materials and gate functionalization enhance in vitro detection performance. Crucially, we evaluate the emerging transition toward in vivo applications, addressing the technological hurdles of signal fidelity and tissue-device interfaces in complex biological systems.
SN  - 3004-8656
ER  -