Developing the Longitudinal Study of Aging in Guatemala (ELEGUA): Rationale and pilot protocol
- 1University of Michigan
Abstract
IntroductionGuatemala is the most populous country in Central America and a setting with unique opportunities for aging research. Approximately 40% of Guatemalas population is Indigenous Maya, who together speak 22 Mayan languages. Currently, there is no population-based aging study in Guatemala and few aging studies in Latin America among Indigenous populations. The Longitudinal Study of Aging in Guatemala (ELEGUA) aims to address these gaps by developing a nationally representative, population-based, longitudinal aging study modeled on the Health and Retirement Study and the Harmonized Cognitive Assessment Protocol, adapted to the cultural and linguistic context of Guatemala. The objective of this protocol is to describe the rationale and design of the ELEGUA pilot survey.
Methods and analysisThe ELEGUA pilot was a cross-sectional household survey of adults aged 40 years or older in Tecpan, Guatemala. Tecpan was chosen because its diverse population facilitated testing of study procedures in both Spanish and Kaqchikel, a common Mayan language. The survey included up to 600 households sampled using a multistage stratified cluster design. Within each household, one individual aged 40 years or older was selected, with oversampling of adults aged 55 years or older. This respondent completed a comprehensive questionnaire, including detailed cognitive tests, and provided physical measurements and a venous blood sample. Household respondents provided information on household economics and family structure, and an informant reported on the individual respondents cognitive function. Data were collected using a computer-assisted personal interviewing system. Planned analyses include survey-weighted descriptive statistics and psychometric evaluation of the cognitive assessments.
Ethics and disseminationEthics approval was obtained from the ethics committees of the Institute of Nutrition of Central America and Panama, Maya Health Alliance, and the University of Michigan. Results will be disseminated through publications in peer-reviewed journals and presentations to local, national, and international audiences.
Strengths and limitations of this studyO_LIThe Longitudinal Study of Aging in Guatemala (ELEGUA) aims to be the first population-based aging study in Guatemala, with instruments adapted from the Health and Retirement Study (HRS) International Network of Studies and the Harmonized Cognitive Assessment Protocol (HCAP). C_LIO_LIThe pilot survey, including the full HCAP cognitive battery, was administered in Spanish and Kaqchikel, a commonly spoken Mayan language in Guatemala. C_LIO_LIThe survey included a rigorous probabilistic multistage stratified cluster sampling design based on national census maps and household listings. C_LIO_LIField procedures, including computer-assisted personal interviewing, physical measurements, and venous blood collection, were piloted under conditions approximating those of the planned national study. C_LIO_LIAs a cross-sectional pilot in a single municipality, the study was designed to test procedures rather than to achieve statistical precision, and findings are not intended to generalize to all regions in Guatemala. C_LI
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BibTeX
@misc{corzantes2026developing,
title = {{Developing the Longitudinal Study of Aging in Guatemala (ELEGUA): Rationale and pilot protocol}},
author = {K. Corzantes and K. Choy and S. Adar and L. F. Castellanos and A. L. Gross and K. M. Langa and P. Rohloff and B. Weerman and E. Briceno and M. Ramirez-Zea and J. Behrman and D. Flood},
howpublished = {medRxiv},
year = {2026},
month = aug,
doi = {10.64898/2026.08.26.26361136},
url = {https://www.medrxiv.org/content/10.64898/2026.08.26.26361136v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Developing the Longitudinal Study of Aging in Guatemala (ELEGUA): Rationale and pilot protocol
AU - K. Corzantes
AU - K. Choy
AU - S. Adar
AU - L. F. Castellanos
AU - A. L. Gross
AU - K. M. Langa
AU - P. Rohloff
AU - B. Weerman
AU - E. Briceno
AU - M. Ramirez-Zea
AU - J. Behrman
AU - D. Flood
PY - 2026
DA - 2026/08/26
PB - medRxiv
DO - 10.64898/2026.08.26.26361136
UR - https://www.medrxiv.org/content/10.64898/2026.08.26.26361136v1
AB - IntroductionGuatemala is the most populous country in Central America and a setting with unique opportunities for aging research. Approximately 40% of Guatemalas population is Indigenous Maya, who together speak 22 Mayan languages. Currently, there is no population-based aging study in Guatemala and few aging studies in Latin America among Indigenous populations. The Longitudinal Study of Aging in Guatemala (ELEGUA) aims to address these gaps by developing a nationally representative, population-based, longitudinal aging study modeled on the Health and Retirement Study and the Harmonized Cognitive Assessment Protocol, adapted to the cultural and linguistic context of Guatemala. The objective of this protocol is to describe the rationale and design of the ELEGUA pilot survey. Methods and analysisThe ELEGUA pilot was a cross-sectional household survey of adults aged 40 years or older in Tecpan, Guatemala. Tecpan was chosen because its diverse population facilitated testing of study procedures in both Spanish and Kaqchikel, a common Mayan language. The survey included up to 600 households sampled using a multistage stratified cluster design. Within each household, one individual aged 40 years or older was selected, with oversampling of adults aged 55 years or older. This respondent completed a comprehensive questionnaire, including detailed cognitive tests, and provided physical measurements and a venous blood sample. Household respondents provided information on household economics and family structure, and an informant reported on the individual respondents cognitive function. Data were collected using a computer-assisted personal interviewing system. Planned analyses include survey-weighted descriptive statistics and psychometric evaluation of the cognitive assessments. Ethics and disseminationEthics approval was obtained from the ethics committees of the Institute of Nutrition of Central America and Panama, Maya Health Alliance, and the University of Michigan. Results will be disseminated through publications in peer-reviewed journals and presentations to local, national, and international audiences. Strengths and limitations of this studyO_LIThe Longitudinal Study of Aging in Guatemala (ELEGUA) aims to be the first population-based aging study in Guatemala, with instruments adapted from the Health and Retirement Study (HRS) International Network of Studies and the Harmonized Cognitive Assessment Protocol (HCAP). C_LIO_LIThe pilot survey, including the full HCAP cognitive battery, was administered in Spanish and Kaqchikel, a commonly spoken Mayan language in Guatemala. C_LIO_LIThe survey included a rigorous probabilistic multistage stratified cluster sampling design based on national census maps and household listings. C_LIO_LIField procedures, including computer-assisted personal interviewing, physical measurements, and venous blood collection, were piloted under conditions approximating those of the planned national study. C_LIO_LIAs a cross-sectional pilot in a single municipality, the study was designed to test procedures rather than to achieve statistical precision, and findings are not intended to generalize to all regions in Guatemala. C_LI
ER -