Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Tendon Regeneration: Insights into Inflammatory and Angiogenesis Modulation
- 1Department of Biology, Faculty Mathematics and Natural Sciences, Universitas Indonesia, Jl. Prof. Dr. Mahar Mardjono, Depok 16424, Indonesia
- 2Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta 10430, Indonesia
Abstract
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are a promising cell-free therapeutic in preclinical models of tendon healing. However, clinical translation remains to be demonstrated. MSC-EVs modulate two critical and interlinked processes in tendon repair inflammation and angiogenesis primarily via delivery of bioactive cargo such as microRNAs and proteins. In inflammation, MSC-EVs promote the transition of macrophages from a pro-inflammatory (M1) to an anti-inflammatory (M2) phenotype, enhancing the resolution of inflammation. In angiogenesis, MSC-EVs facilitate endothelial cell proliferation and migration, promoting early vascularization followed by vascular regression during later healing. Recent advancements in MSC-EVs engineering and delivery systems have improved their therapeutic efficacy, yet further research is essential to elucidate their molecular mechanisms and achieve precise therapeutic outcomes.
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BibTeX
@article{fernanda2026therapeutic,
title = {{Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Tendon Regeneration: Insights into Inflammatory and Angiogenesis Modulation}},
author = {Daffa Raditya Fernanda and Radiana Dhewayani Antarianto and Abinawanto Abinawanto and Retno Lestari},
journal = {International Journal of Molecular and Cellular Medicine},
year = {2026},
month = jun,
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles for Tendon Regeneration: Insights into Inflammatory and Angiogenesis Modulation
AU - Daffa Raditya Fernanda
AU - Radiana Dhewayani Antarianto
AU - Abinawanto Abinawanto
AU - Retno Lestari
PY - 2026
DA - 2026/06/01
JO - International Journal of Molecular and Cellular Medicine
AB - Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are a promising cell-free therapeutic in preclinical models of tendon healing. However, clinical translation remains to be demonstrated. MSC-EVs modulate two critical and interlinked processes in tendon repair inflammation and angiogenesis primarily via delivery of bioactive cargo such as microRNAs and proteins. In inflammation, MSC-EVs promote the transition of macrophages from a pro-inflammatory (M1) to an anti-inflammatory (M2) phenotype, enhancing the resolution of inflammation. In angiogenesis, MSC-EVs facilitate endothelial cell proliferation and migration, promoting early vascularization followed by vascular regression during later healing. Recent advancements in MSC-EVs engineering and delivery systems have improved their therapeutic efficacy, yet further research is essential to elucidate their molecular mechanisms and achieve precise therapeutic outcomes.
SN - 2251-9637
SN - 2251-9645
ER -