Anti-Aging Efficacy of a Home-use red and Infrared Light-Emitting Diode Mask and a Cream: Ex Vivo and Clinical Evaluations in Women With Mature Skin.
- 1Laboratoires, Pontoise, France.
- 2Gredeco, Paris, France.
Abstract
Background
Photobiomodulation has gained considerable attention for its potential in various dermatological applications. We assessed the anti-aging effects of a home-use face-fit mask combining 630 and 850 nm light-emitting diodes (LEDs) and an anti-aging cream in ex vivo and prospective exploratory clinical studies. Both products are commercially available.Methods
Skin samples from six women aged 39─55 years were either left untreated or received topical treatments for 7 days: LED irradiation (7-minute sessions) or cream (2 mg/cm²), or both. In the clinical study, women aged 49─65 years (n = 50) applied the cream daily to the face and neck for 56 days and used the mask 3─4 times per week.Results
Compared to untreated skin samples, the combination of LEDs and cream increased the expression of elastin (+29.6%) and collagen 1 (+7.6%) (p< 0.05 for both). The expression of elastin also increased following treatment with the LEDs alone (+26.1%; p< 0.05). the effect of LEDs and cream combined treatment was demonstrated on collagen 1 expression, with a similar trend observed for elastin expression. In the clinical study, investigator-assessed clinical scores showed significant progressive improvements from baseline, reaching +57.1% for skin radiance, -39.4% for pore dilatation, and -24.2% for crow's feet wrinkle depth at Day 56 (p< 0.0001 for all). Participants also perceived significantly improved skin radiance and smoothing of face and neck wrinkles throughout the study.Conclusion
The LED mask and the anti-aging cream led to visible and clinically measurable skin signs of ageing reduction versus baseline. The increase in collagen I and elastin expression observed in the ex vivo study could contribute to the visible reduction in signs of aging demonstrated in the clinical study.
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BibTeX
@article{bellanger2026antiaging,
title = {{Anti-Aging Efficacy of a Home-use red and Infrared Light-Emitting Diode Mask and a Cream: Ex Vivo and Clinical Evaluations in Women With Mature Skin.}},
author = {Aurore Bellanger and Christelle Guéré and Sylvie Boisnic and Dorothée Godet},
journal = {Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)},
year = {2026},
month = oct,
doi = {10.1111/srt.70395},
url = {https://europepmc.org/article/MED/42920345},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Anti-Aging Efficacy of a Home-use red and Infrared Light-Emitting Diode Mask and a Cream: Ex Vivo and Clinical Evaluations in Women With Mature Skin.
AU - Aurore Bellanger
AU - Christelle Guéré
AU - Sylvie Boisnic
AU - Dorothée Godet
PY - 2026
DA - 2026/10/01
JO - Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
DO - 10.1111/srt.70395
UR - https://europepmc.org/article/MED/42920345
AB - Background Photobiomodulation has gained considerable attention for its potential in various dermatological applications. We assessed the anti-aging effects of a home-use face-fit mask combining 630 and 850 nm light-emitting diodes (LEDs) and an anti-aging cream in ex vivo and prospective exploratory clinical studies. Both products are commercially available.Methods Skin samples from six women aged 39─55 years were either left untreated or received topical treatments for 7 days: LED irradiation (7-minute sessions) or cream (2 mg/cm²), or both. In the clinical study, women aged 49─65 years (n = 50) applied the cream daily to the face and neck for 56 days and used the mask 3─4 times per week.Results Compared to untreated skin samples, the combination of LEDs and cream increased the expression of elastin (+29.6%) and collagen 1 (+7.6%) (p< 0.05 for both). The expression of elastin also increased following treatment with the LEDs alone (+26.1%; p< 0.05). the effect of LEDs and cream combined treatment was demonstrated on collagen 1 expression, with a similar trend observed for elastin expression. In the clinical study, investigator-assessed clinical scores showed significant progressive improvements from baseline, reaching +57.1% for skin radiance, -39.4% for pore dilatation, and -24.2% for crow's feet wrinkle depth at Day 56 (p< 0.0001 for all). Participants also perceived significantly improved skin radiance and smoothing of face and neck wrinkles throughout the study.Conclusion The LED mask and the anti-aging cream led to visible and clinically measurable skin signs of ageing reduction versus baseline. The increase in collagen I and elastin expression observed in the ex vivo study could contribute to the visible reduction in signs of aging demonstrated in the clinical study.
SN - 0909-752X
SN - 1600-0846
ER -