Effect of Cyclodextrin Type on the Photopolymerization and Network Properties of Oligo(L-lactide)-Extended Poly(ethylene glycol) Formulations
- 1Department of Polymer and Biomaterials Sciences, West Pomeranian University of Technology in Szczecin, Al. Piastów 45, Poland
- 2Centre for Advanced Materials and Processing Technologies – MATPRO, West Pomeranian University of Technology in Szczecin, Al. Piastów 45, Szczecin, POLAND (PL), 71-310
- 3Department of Organic and Physical Chemistry, West Pomeranian University of Technology in Szczecin, Al. Piastów 42, Poland
Abstract
Cyclodextrins (CDs) are widely used as supramolecular components to provide a platform for designing material properties through non-covalent interactions. In this study, we report how the CD type influences the photopolymerization and network properties of a methacrylated telechelic oligo(L-lactide)-extended poly(ethylene glycol) precursor (PLA-PEG-PLA), denoted MPL with three different cyclodextrins (α-CD, β-CD and 2-hydroxypropyl-β-CD (HP-β-CD)) prepared at a 1:2 MPL:CD molar feed ratio. The effect of cyclodextrin type on the chemical structure, inclusion geometry, thermal behaviour, and physicochemical properties of the resulting material, as well as on their photopolymerization process, was systematically studied using FTIR spectroscopy, 1D and 2D proton (ROESY/NOESY) 1 H NMR techniques, and differential scanning calorimetry. Molecular docking was used to visualize plausible inclusion geometries. The influence of photoinitiator type and concentration on polymerisation efficiency was examined, and the cytocompatibility of the cured materials was assessed against L929 fibroblasts. The results showed that the nature of cyclodextrin affects the strength of supramolecular association and systematically influences photo-initiated polymerization kinetics, network formation, and macroscopic material properties. Overall, this work highlights the design of cyclodextrin-mediated supramolecular macromonomer materials and outlines their potential as a tunable photo-curable host-guest polymer network.
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BibTeX
@misc{pillai2026effect,
title = {{Effect of Cyclodextrin Type on the Photopolymerization and Network Properties of Oligo(L-lactide)-Extended Poly(ethylene glycol) Formulations}},
author = {Archana Sumohan Pillai and Nicolas Maciejewicz-Kamiński and Paweł Sać and Gokhan Demirci and Tomasz Idzik and Jacek G Sośnicki and Miroslawa El Fray},
howpublished = {ChemRxiv},
year = {2026},
month = oct,
doi = {10.26434/chemrxiv.10001805/v3},
url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.10001805/v3},
note = {CC BY},
}
RIS
TY - UNPB
TI - Effect of Cyclodextrin Type on the Photopolymerization and Network Properties of Oligo(L-lactide)-Extended Poly(ethylene glycol) Formulations
AU - Archana Sumohan Pillai
AU - Nicolas Maciejewicz-Kamiński
AU - Paweł Sać
AU - Gokhan Demirci
AU - Tomasz Idzik
AU - Jacek G Sośnicki
AU - Miroslawa El Fray
PY - 2026
DA - 2026/10/20
PB - ChemRxiv
DO - 10.26434/chemrxiv.10001805/v3
UR - https://chemrxiv.org/doi/full/10.26434/chemrxiv.10001805/v3
AB - Cyclodextrins (CDs) are widely used as supramolecular components to provide a platform for designing material properties through non-covalent interactions. In this study, we report how the CD type influences the photopolymerization and network properties of a methacrylated telechelic oligo(L-lactide)-extended poly(ethylene glycol) precursor (PLA-PEG-PLA), denoted MPL with three different cyclodextrins (α-CD, β-CD and 2-hydroxypropyl-β-CD (HP-β-CD)) prepared at a 1:2 MPL:CD molar feed ratio. The effect of cyclodextrin type on the chemical structure, inclusion geometry, thermal behaviour, and physicochemical properties of the resulting material, as well as on their photopolymerization process, was systematically studied using FTIR spectroscopy, 1D and 2D proton (ROESY/NOESY) 1 H NMR techniques, and differential scanning calorimetry. Molecular docking was used to visualize plausible inclusion geometries. The influence of photoinitiator type and concentration on polymerisation efficiency was examined, and the cytocompatibility of the cured materials was assessed against L929 fibroblasts. The results showed that the nature of cyclodextrin affects the strength of supramolecular association and systematically influences photo-initiated polymerization kinetics, network formation, and macroscopic material properties. Overall, this work highlights the design of cyclodextrin-mediated supramolecular macromonomer materials and outlines their potential as a tunable photo-curable host-guest polymer network.
ER -