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Peer-reviewedCC BYCell Stress

MicroRNA as key players in skin regeneration and anti-aging pathways

  • Hanieh Azizi1
  • Reza Moghadasali2
  • Amir Mohammad Amirkhani3
  • Ehsan Taghiabadi3
  • Mohammad Ali Nilforoushzadeh3
  1. 1Department of Advanced Biological Sciences and Technologies, University of Science and Culture, Tehran, Iran
  2. 2Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
  3. 3Skin and Stem Cell Research Center, Tehran University of Medical Science, Iran
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Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNAs that significantly impact skin rejuvenation via gene regulation that is involved in mechanisms such as regeneration, wound repair, and aging. By potentially shifting pathways modulating inflammation, cell proliferation, and extracellular matrix remodeling, they can be considered as an effective anti-aging intervention candidate. Such molecular mechanisms of miRNAs in cutaneous homeostasis of fibroblast activity, keratinocyte differentiation, and collagen synthesis are provided in the current review. Representative miRNAs such as miRNA-124, miRNA-377, miRNA-34 family, and miRNA-29 family, miRNA-302b-3p, miRNA-361-5p, miRNA-146a, miRNA-21, miRNA-181-a, miRNA155 demonstrate distinct roles in regulating wound healing, inflammatory resolution, maintaining the extracellular matrix, and handling oxidative stress. This review highlights current knowledge of miRNA-mediated regulation in skin regeneration and aging and synthesizes recent findings on their individual functions in these biological processes. It also emphasizes the potential of miRNA-based interventions as a next generation approach to skin rejuvenation, while addressing existing challenges that must be resolved before these strategies can be translated into clinical applications.

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Cite

BibTeXRIS
BibTeX
@article{azizi2026microrna,
  title = {{MicroRNA as key players in skin regeneration and anti-aging pathways}},
  author = {Hanieh Azizi and Reza Moghadasali and Amir Mohammad Amirkhani and Ehsan Taghiabadi and Mohammad Ali Nilforoushzadeh},
  journal = {Cell Stress},
  year = {2026},
  month = oct,
  doi = {10.15698/cst2026.10.322},
  url = {https://doi.org/10.15698/cst2026.10.322},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - MicroRNA as key players in skin regeneration and anti-aging pathways
AU  - Hanieh Azizi
AU  - Reza Moghadasali
AU  - Amir Mohammad Amirkhani
AU  - Ehsan Taghiabadi
AU  - Mohammad Ali Nilforoushzadeh
PY  - 2026
DA  - 2026/10/01
JO  - Cell Stress
DO  - 10.15698/cst2026.10.322
UR  - https://doi.org/10.15698/cst2026.10.322
AB  - MicroRNAs (miRNAs) are a class of small non-coding RNAs that significantly impact skin rejuvenation via gene regulation that is involved in mechanisms such as regeneration, wound repair, and aging. By potentially shifting pathways modulating inflammation, cell proliferation, and extracellular matrix remodeling, they can be considered as an effective anti-aging intervention candidate. Such molecular mechanisms of miRNAs in cutaneous homeostasis of fibroblast activity, keratinocyte differentiation, and collagen synthesis are provided in the current review. Representative miRNAs such as miRNA-124, miRNA-377, miRNA-34 family, and miRNA-29 family, miRNA-302b-3p, miRNA-361-5p, miRNA-146a, miRNA-21, miRNA-181-a, miRNA155 demonstrate distinct roles in regulating wound healing, inflammatory resolution, maintaining the extracellular matrix, and handling oxidative stress. This review highlights current knowledge of miRNA-mediated regulation in skin regeneration and aging and synthesizes recent findings on their individual functions in these biological processes. It also emphasizes the potential of miRNA-based interventions as a next generation approach to skin rejuvenation, while addressing existing challenges that must be resolved before these strategies can be translated into clinical applications.
SN  - 2523-0204
ER  -