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Peer-reviewedCC BY-NC 4.0BMJ Open

High-intensity interval training and moderate-intensity continuous training versus usual care in adults with familial hypercholesterolaemia: protocol for the UPPA-FH three-arm randomised trial

  • José Antonio Vargas-Hitos1,2
  • Pablo González-Bustos1,2
  • María José Martín-Jáimez3,4
  • Jesús Orellana-Jaén5,6
  • Antonio Diaz-Chamorro1,2
  • Blanca Sánchez-Checa1,2
  • Alberto Ortiz-Parra1,2
  • Lauro Quesada-Jiménez1,2
  • Pablo García-Mateo1,2
  • Elena Martínez-Rosales7,8
  • Cristian Garcia-Sanchez7,8
  • Andrés Baena-Raya9
27 more authors
  • Alba Hernandez-Martinez10,11
  • Rocío Sánchez-Sánchez2,12
  • María Emiliana Bellón-Guardia2,12
  • Yolanda García-Rivero2,12
  • Antonia Román-Muñoz2,12
  • Álvaro Contreras-Rodríguez2,12
  • Antonio Jesús Lainez Ramos-Bossini2,13,14
  • Genaro López-Milena13
  • Ricardo Rivera-López2,15
  • Rafael Peñafiel Burkhardt2,15
  • Víctor López-Espinosa2,15
  • María Del Señor López Vélez2,16
  • Fernando Rodríguez-Alemán2,16
  • Javier Blanco-Ramos5,17
  • Ismael F Aomar-Millán2,18
  • Juan Antonio Montes-Romero19
  • María Luisa Fernández-Almira19
  • Purificación Sánchez-López19
  • Tania Romacho20
  • Ana Cristina Abreu21
  • Ignacio Fernández21
  • Fernando Jaén-Águila2
  • Juan Diego Mediavilla-García1,2
  • Nuria Navarrete-Navarrete1,2
  • Robin Christensen22
  • Blanca Gavilán-Carrera23,24
  • Alberto Soriano-Maldonado25,26
26 affiliations
  1. 1Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada, Spain.
  2. 2ibs.GRANADA, Granada, Spain.
  3. 3Department of Education, University of Almeria, Almería, Spain.
  4. 4SPORT Research Group (CTS-1024), CIBIS (Centro de Investigación para el Bienestar y la Inclusión Social) Research Center, University of Almería, Almería, Spain.
  5. 5FIBAO, Granada, Spain.
  6. 6Departamento de Educación Física y Deporte, Universidad de Sevilla, Sevilla, Spain.
  7. 7Department of Physiology, University of Granada, Granada, Spain.
  8. 8Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
  9. 9Department of Medicine, Division of Endocrinology & Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, Netherlands.
  10. 10Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
  11. 11CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
  12. 12Department of Nuclear Medicine, Hospital Universitario Virgen de las Nieves, Granada, Spain.
  13. 13Department of Radiology, Hospital Universitario Virgen de las Nieves, Granada, Spain.
  14. 14Department of Human Anatomy and Embriology, University of Granada, Granada, Spain.
  15. 15Department of Cardiology, Hospital Universitario Virgen de las Nieves, Granada, Spain.
  16. 16Department of Clinical Analysis, Hospital Universitario Virgen de las Nieves, Granada, Spain.
  17. 17Department of Educational Psychology and Psychobiology, International University of La Rioja, Logroño, Spain.
  18. 18Department of Internal Medicine, Hospital Universitario San Cecilio, Granada, Spain.
  19. 19Department of Internal Medicine, Hospital Universitario Torrecárdenas, Almería, Spain.
  20. 20Department of Nursing, Physiotherapy and Medicine, Chronic Complications of Diabetes Lab (ChroCoDiL), Biomedicine, Integrative Physiology and Therpeutics (BIT) CTS-1163, University of Almería, Almería, Spain.
  21. 21Department of Chemistry and Physics, Research Centre CIAIMBITAL, University of Almería, Almería, Spain.
  22. 22The Parker Institute: MSU, Copenhagen University Hospital, Frederiksberg, Copenhagen, Denmark.
  23. 23Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain [email protected].
  24. 24Department of Physical Education and Sport, University of Granada, Granada, Spain.
  25. 25Department of Education, Faculty of Education Sciences, University of Almería, Almería, Spain.
  26. 26SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almería, Almería, Spain.
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BibTeXRIS
BibTeX
@article{vargashitos2026highintensity,
  title = {{High-intensity interval training and moderate-intensity continuous training versus usual care in adults with familial hypercholesterolaemia: protocol for the UPPA-FH three-arm randomised trial}},
  author = {José Antonio Vargas-Hitos and Pablo González-Bustos and María José Martín-Jáimez and Jesús Orellana-Jaén and Antonio Diaz-Chamorro and Blanca Sánchez-Checa and Alberto Ortiz-Parra and Lauro Quesada-Jiménez and Pablo García-Mateo and Elena Martínez-Rosales and Cristian Garcia-Sanchez and Andrés Baena-Raya and Alba Hernandez-Martinez and Rocío Sánchez-Sánchez and María Emiliana Bellón-Guardia and Yolanda García-Rivero and Antonia Román-Muñoz and Álvaro Contreras-Rodríguez and Antonio Jesús Lainez Ramos-Bossini and Genaro López-Milena and Ricardo Rivera-López and Rafael Peñafiel Burkhardt and Víctor López-Espinosa and María Del Señor López Vélez and Fernando Rodríguez-Alemán and Javier Blanco-Ramos and Ismael F Aomar-Millán and Juan Antonio Montes-Romero and María Luisa Fernández-Almira and Purificación Sánchez-López and Tania Romacho and Ana Cristina Abreu and Ignacio Fernández and Fernando Jaén-Águila and Juan Diego Mediavilla-García and Nuria Navarrete-Navarrete and Robin Christensen and Blanca Gavilán-Carrera and Alberto Soriano-Maldonado},
  journal = {BMJ Open},
  year = {2026},
  month = oct,
  doi = {10.1136/bmjopen-2025-114501},
  url = {https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2025-114501},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - High-intensity interval training and moderate-intensity continuous training versus usual care in adults with familial hypercholesterolaemia: protocol for the UPPA-FH three-arm randomised trial
AU  - José Antonio Vargas-Hitos
AU  - Pablo González-Bustos
AU  - María José Martín-Jáimez
AU  - Jesús Orellana-Jaén
AU  - Antonio Diaz-Chamorro
AU  - Blanca Sánchez-Checa
AU  - Alberto Ortiz-Parra
AU  - Lauro Quesada-Jiménez
AU  - Pablo García-Mateo
AU  - Elena Martínez-Rosales
AU  - Cristian Garcia-Sanchez
AU  - Andrés Baena-Raya
AU  - Alba Hernandez-Martinez
AU  - Rocío Sánchez-Sánchez
AU  - María Emiliana Bellón-Guardia
AU  - Yolanda García-Rivero
AU  - Antonia Román-Muñoz
AU  - Álvaro Contreras-Rodríguez
AU  - Antonio Jesús Lainez Ramos-Bossini
AU  - Genaro López-Milena
AU  - Ricardo Rivera-López
AU  - Rafael Peñafiel Burkhardt
AU  - Víctor López-Espinosa
AU  - María Del Señor López Vélez
AU  - Fernando Rodríguez-Alemán
AU  - Javier Blanco-Ramos
AU  - Ismael F Aomar-Millán
AU  - Juan Antonio Montes-Romero
AU  - María Luisa Fernández-Almira
AU  - Purificación Sánchez-López
AU  - Tania Romacho
AU  - Ana Cristina Abreu
AU  - Ignacio Fernández
AU  - Fernando Jaén-Águila
AU  - Juan Diego Mediavilla-García
AU  - Nuria Navarrete-Navarrete
AU  - Robin Christensen
AU  - Blanca Gavilán-Carrera
AU  - Alberto Soriano-Maldonado
PY  - 2026
DA  - 2026/10/21
JO  - BMJ Open
DO  - 10.1136/bmjopen-2025-114501
UR  - https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2025-114501
SN  - 2044-6055
SN  - 2044-6055
ER  -