Skip to content
DraconiticResearch
Search Sources API
203,203 studies31 sourcesUpdated 13 min ago
Peer-reviewedCC BY-NC-ND 4.0Alzheimer's & Dementia

Caregiver positivity as a psychosocial modifier of lecanemab‐related outcomes in Alzheimer's disease: A multicenter longitudinal study in China

  • Wenjing Wu1
  • Huayan Liu2
  • Yun Liang1
  • Huai'an Li3
  • Jinhong Zhang4
  • Zhen Sun5
  • Yehua Song6
  • Min Fei7
  • Hao Wu1
  • Mo Jiang8
  • Shiyv Fan9
  • Chaohui Zhou10
3 more authors
  • Yv Cao10
  • Hui Chen10
  • Shuai Liu1
10 affiliations
  1. 1Department of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases Huanhu Hospital Affiliated to Tianjin Medical University Tianjin China
  2. 2Department of Neurology The First Hospital of China Medical University Shenyang China
  3. 3Department of Neurology, Qinhuangdao Hospital of Dongfang Hospital Beijing University of Chinese Medicine (Qinhuangdao Hospital of Traditional Chinese Medicine) Qinhuangdao China
  4. 4Department of Neurology Cangzhou People's Hospital Cangzhou China
  5. 5Department of Neurology, The Sixth Clinical College of Changzhi Medical College Linfen Central Hospital Linfen China
  6. 6Department of Neurology The Second Affiliated Hospital of Xiamen Medical University Xiamen China
  7. 7Department of Neurology Yuncheng Central Hospital Yuncheng China
  8. 8Medical Department Eisai China Inc. Shanghai China
  9. 9Department of Acupuncture and Moxibustion Tianjin University of Traditional Chinese Medicine Tianjin China
  10. 10School of Nursing Tianjin Medical University Tianjin China
Read full textPDFDOICite

Abstract

INTRODUCTION: Real‐world modifiers of lecanemab benefit in Alzheimer's disease (AD) remain elusive. We examined associations between caregiver positivity and longitudinal outcomes in AD.

METHODS: This seven‐center longitudinal study followed 127 biomarker‐supported AD patient–caregiver dyads over 18 months. Mixed‐effects, spline, and propensity‐score analyses evaluated continuous Positive Aspects of Caregiving (PAC) scores.

RESULTS: Higher baseline PAC scale scores were associated with more favorable 18‐month outcomes in cognition (Mini‐Mental State Examination (MMSE): β = 0.42, 95% confidence interval [CI]: 0.24–0.59; p < 0.001), daily function (Alzheimer's Disease Cooperative Study–Activities of Daily Living [ADCS‐ADL]: β = 0.68, 95% CI: 0.42–0.93; p < 0.001), disease severity (Clinical Dementia Rating–Sum of Boxes [CDR‐SB]: β = −0.26, 95% CI: −0.37 to −0.14; P < 0.001), patient quality of life (Quality of Life in Alzheimer's Disease [QOL‐AD]: β = 0.53, 95% CI: 0.34–0.71; p < 0.001), and lower apathy ( β = −0.09, 95% CI: −0.16 to −0.03; p = 0.003); these associations remained significant after multiplicity correction (all q’s ≤ 0.004). Patient QOL‐AD showed the most consistent sensitivity‐analysis association. Apathy was associated with caregiver burden and caregiver quality of life, but mediation was not established.

DISCUSSION: Caregiver positivity may stratify lecanemab efficacy in AD, supporting psychosocial assessment in personalized, caregiver‐inclusive management pathways.

Related

  1. Real‐world clinical, biomarker, and imaging outcomes of lecanemab in Alzheimer's disease: a multicenter longitudinal cohort study in Jiangsu, China
    Limoran Tang, Xicheng Chen, Li Zhang +31
    Alzheimer's & DementiaPeer-reviewedCC BY 4.0Full textPhysiologyPMC
  2. Psychosocial trajectories and CD4+/CD8+ ratio normalization among adults with HIV in Changsha, China: a 9-year longitudinal cohort study
    Xinya Tu, Yue Liu, Zhi Xie +2
    BMC Public HealthPeer-reviewedCC BY 4.0Epidemiology & public healthCrossref
  3. Young people with chronic health conditions: longitudinal study of psychosocial assessment and digital health service use across transfer of care
    Anna Alanen, Mira Kallio, Sanna Salanterä +1
    BMC PediatricsPeer-reviewedCC BY-NC-ND 4.0Full textObstetrics, gynaecology & paediatricsDOAJPMC
  4. Stage-Specific Associations of Automated RPR With Treponema pallidum qPCR Positivity and Cycle Threshold in Early Symptomatic Syphilis: A Multicenter Study Using Specimens Collected During Routine Care
    A. Kasamatsu, Y. Ohama, Y. Tomo +6
    medRxivPreprintCC BY-NCFull textInfectious diseasemedRxiv
  5. Dancing to wellbeing: a three-wave longitudinal mixed-methods study of Rock “n” Roll Dancesport and psychosocial outcomes in Chinese university students
    Yuanmei He, Jialin Wu
    Frontiers in public healthPeer-reviewedCC BYFull textEpidemiology & public healthEurope PMCCrossref

Cite

BibTeXRIS
BibTeX
@article{wu2026caregiver,
  title = {{Caregiver positivity as a psychosocial modifier of lecanemab‐related outcomes in Alzheimer's disease: A multicenter longitudinal study in China}},
  author = {Wenjing Wu and Huayan Liu and Yun Liang and Huai'an Li and Jinhong Zhang and Zhen Sun and Yehua Song and Min Fei and Hao Wu and Mo Jiang and Shiyv Fan and Chaohui Zhou and Yv Cao and Hui Chen and Shuai Liu},
  journal = {Alzheimer's \& Dementia},
  year = {2026},
  month = oct,
  doi = {10.1002/alz.71894},
  url = {https://doi.org/10.1002/alz.71894},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Caregiver positivity as a psychosocial modifier of lecanemab‐related outcomes in Alzheimer's disease: A multicenter longitudinal study in China
AU  - Wenjing Wu
AU  - Huayan Liu
AU  - Yun Liang
AU  - Huai'an Li
AU  - Jinhong Zhang
AU  - Zhen Sun
AU  - Yehua Song
AU  - Min Fei
AU  - Hao Wu
AU  - Mo Jiang
AU  - Shiyv Fan
AU  - Chaohui Zhou
AU  - Yv Cao
AU  - Hui Chen
AU  - Shuai Liu
PY  - 2026
DA  - 2026/10/27
JO  - Alzheimer's & Dementia
DO  - 10.1002/alz.71894
UR  - https://doi.org/10.1002/alz.71894
AB  - INTRODUCTION: Real‐world modifiers of lecanemab benefit in Alzheimer's disease (AD) remain elusive. We examined associations between caregiver positivity and longitudinal outcomes in AD.  METHODS: This seven‐center longitudinal study followed 127 biomarker‐supported AD patient–caregiver dyads over 18 months. Mixed‐effects, spline, and propensity‐score analyses evaluated continuous Positive Aspects of Caregiving (PAC) scores.  RESULTS: Higher baseline PAC scale scores were associated with more favorable 18‐month outcomes in cognition (Mini‐Mental State Examination (MMSE): β = 0.42, 95% confidence interval [CI]: 0.24–0.59; p < 0.001), daily function (Alzheimer's Disease Cooperative Study–Activities of Daily Living [ADCS‐ADL]: β = 0.68, 95% CI: 0.42–0.93; p < 0.001), disease severity (Clinical Dementia Rating–Sum of Boxes [CDR‐SB]: β = −0.26, 95% CI: −0.37 to −0.14; P < 0.001), patient quality of life (Quality of Life in Alzheimer's Disease [QOL‐AD]: β = 0.53, 95% CI: 0.34–0.71; p < 0.001), and lower apathy ( β = −0.09, 95% CI: −0.16 to −0.03; p = 0.003); these associations remained significant after multiplicity correction (all q’s ≤ 0.004). Patient QOL‐AD showed the most consistent sensitivity‐analysis association. Apathy was associated with caregiver burden and caregiver quality of life, but mediation was not established.  DISCUSSION: Caregiver positivity may stratify lecanemab efficacy in AD, supporting psychosocial assessment in personalized, caregiver‐inclusive management pathways.
SN  - 1552-5260
SN  - 1552-5279
ER  -