The relationship between endothelial activation and stress index (EASIX) and the incidence of major adverse cardiovascular events in acute myocardial infarction patients admitted in emergency department.
5 affiliations
- 1Department of Emergency Medicine, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
- 2Sepsis Research Center of Hunan Provincial Geriatric Institute, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.
- 3Department of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
- 4Department of Neurology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.
- 5Department of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China. [email protected].
Abstract
Objective
In this study, we aimed to explore the relationship between endothelial activation and stress index (EASIX) and the incidence of major adverse cardiovascular events (MACE) in acute myocardial infarction (AMI) patients.Method
This retrospective study was based on the clinical data of the AMI patients admitted in emergency department of Changsha Central Hospital from August 2020 to January 2023. Different models were constructed by multivariable regression analysis for investigating the relationship between EASIX index and MACE risk. Restricted cubic spline (RCS) analysis was utilized for further validating the potential nonlinear relationship. The receiver-operator characteristic (ROC) analysis of EASIX index for predicting MACE risk in AMI was done.Results
805 AMI patients with 193 individuals in MACE group were included. After adjusting potential confounders, with per unit increasement in EASIX index, the risk of MACE increased by 16% (OR = 1.16, 95%CI: 1.04-1.29, p = 0.0054). The RCS showed the nonlinear relationship between EASIX index and the incidence of MACE was not significant. The predictive performances of EASIX index were showed as follow: an AUC of 0.687 (95%CI:0.642-0.732) and a cut-off value of 2.42.Conclusion
A significant relationship between EASIX index and the incidence of MACE in AMI was identified.
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BibTeX
@article{cao2026relationship,
title = {{The relationship between endothelial activation and stress index (EASIX) and the incidence of major adverse cardiovascular events in acute myocardial infarction patients admitted in emergency department.}},
author = {Yan Cao and Bowen Xiong and Tangyi Zeng and Liudang He and Yingjie Su and Ning Ding},
journal = {BMC emergency medicine},
year = {2026},
month = aug,
doi = {10.1186/s12873-026-01682-w},
url = {https://europepmc.org/article/MED/42972255},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - The relationship between endothelial activation and stress index (EASIX) and the incidence of major adverse cardiovascular events in acute myocardial infarction patients admitted in emergency department.
AU - Yan Cao
AU - Bowen Xiong
AU - Tangyi Zeng
AU - Liudang He
AU - Yingjie Su
AU - Ning Ding
PY - 2026
DA - 2026/08/01
JO - BMC emergency medicine
DO - 10.1186/s12873-026-01682-w
UR - https://europepmc.org/article/MED/42972255
AB - Objective In this study, we aimed to explore the relationship between endothelial activation and stress index (EASIX) and the incidence of major adverse cardiovascular events (MACE) in acute myocardial infarction (AMI) patients.Method This retrospective study was based on the clinical data of the AMI patients admitted in emergency department of Changsha Central Hospital from August 2020 to January 2023. Different models were constructed by multivariable regression analysis for investigating the relationship between EASIX index and MACE risk. Restricted cubic spline (RCS) analysis was utilized for further validating the potential nonlinear relationship. The receiver-operator characteristic (ROC) analysis of EASIX index for predicting MACE risk in AMI was done.Results 805 AMI patients with 193 individuals in MACE group were included. After adjusting potential confounders, with per unit increasement in EASIX index, the risk of MACE increased by 16% (OR = 1.16, 95%CI: 1.04-1.29, p = 0.0054). The RCS showed the nonlinear relationship between EASIX index and the incidence of MACE was not significant. The predictive performances of EASIX index were showed as follow: an AUC of 0.687 (95%CI:0.642-0.732) and a cut-off value of 2.42.Conclusion A significant relationship between EASIX index and the incidence of MACE in AMI was identified.
SN - 1471-227X
ER -