Detection of high-grade dysplasia and adenocarcinoma in Barrett's esophagus using high-resolution virtual chromoendoscopy versus the Seattle protocol: the CONVERSE study
Abstract
Background: Barrett's esophagus (BE) is a pre-cancerous condition with an increased risk of esophageal adenocarcinoma (EAC). Current surveillance involves white light endoscopy with random biopsies (Seattle Protocol, SP) but has limitations. This study explores high-resolution virtual chromoendoscopy (HRMC) as a potential alternative. Methods: This controlled trial will enroll 110 patients with Barrett's esophagus (BE) across 15 gastroenterology departments in France. Each patient will undergo both HRMC and SP examinations during the same endoscopic procedure. Although the trial is non-randomized, it is important to highlight that the two endoscopists performing either the HRMC or the SP will be blinded to each other's results. Therefore, each patient will serve as their own control. Biopsy decisions will be based on both methods, with any visible lesions resected. The primary objective is to compare the detection rate of HGD and EAC lesions using HRMC with targeted biopsies versus SP with random biopsies. Secondary objectives include comparing detection rates of LGD lesions, procedure time, missed lesions, and cost-effectiveness. Discussion: If HRMC proves superior to SP for detecting HGD and EAC, it could lead to more accurate, efficient, and cost-effective BE surveillance strategies, improving patient outcomes and resource utilization. Trial registration: ClinicalTrials.gov NCT05229783 - First Submitted 2021-12-07.
Related
- High-Resolution Melting (HRM) Assay for Molecular Detection of Calonectria ilicicola in Soybean
- Integrative transcriptomics and reverse network pharmacology prioritize DPP4 and Achyranthes bidentata in Barrett’s esophagus
- The capability of very high-resolution satellite imagery for plot-level early wheat stem rust disease detection, monitoring, and phenotyping in Ethiopia
- Detection of Red Crown Rot of Soybean in Illinois Fields Using High-Resolution Satellite Imagery and Machine Learning
- Single-cell landscape of lymphoid and myeloid heterogeneity across type-stratified craniofacial lesions in polyostotic fibrous dysplasia
BibTeX
@article{queneherve2026detection,
title = {{Detection of high-grade dysplasia and adenocarcinoma in Barrett's esophagus using high-resolution virtual chromoendoscopy versus the Seattle protocol: the CONVERSE study}},
author = {Lucille Quénéhervé and Jean-Benoit Hardouin and Valery-Pierre Riche and Youssouf Compaore and Isabelle Archambeaud and Stephanie Bardot and Iva Jirka Alebic and Monique Marguerite and Cyrielle Letaillandier and Christelle Ratajczak and Océane Pierry and Alexandra Jobert and Gabriel Rahmi and Arthur Berger and David Karsenti and Clara Yzet and Mathieu Pioche and Thierry Barrioz and Irina Tchoumak and Marion Schaefer and Jean-Baptiste Chevaux and Jeremie Jacques and Timothée Wallenhorst and Geoffroy Vanbiervliet and Stéphane Koch and Maximillien Barret and Alexandra Poinas and Emmanuel Coron},
journal = {BMC Gastroenterology},
year = {2026},
month = jul,
doi = {10.1186/s12876-026-05038-3},
url = {https://u-picardie.hal.science/hal-05688256v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Detection of high-grade dysplasia and adenocarcinoma in Barrett's esophagus using high-resolution virtual chromoendoscopy versus the Seattle protocol: the CONVERSE study
AU - Lucille Quénéhervé
AU - Jean-Benoit Hardouin
AU - Valery-Pierre Riche
AU - Youssouf Compaore
AU - Isabelle Archambeaud
AU - Stephanie Bardot
AU - Iva Jirka Alebic
AU - Monique Marguerite
AU - Cyrielle Letaillandier
AU - Christelle Ratajczak
AU - Océane Pierry
AU - Alexandra Jobert
AU - Gabriel Rahmi
AU - Arthur Berger
AU - David Karsenti
AU - Clara Yzet
AU - Mathieu Pioche
AU - Thierry Barrioz
AU - Irina Tchoumak
AU - Marion Schaefer
AU - Jean-Baptiste Chevaux
AU - Jeremie Jacques
AU - Timothée Wallenhorst
AU - Geoffroy Vanbiervliet
AU - Stéphane Koch
AU - Maximillien Barret
AU - Alexandra Poinas
AU - Emmanuel Coron
PY - 2026
DA - 2026/07/08
JO - BMC Gastroenterology
DO - 10.1186/s12876-026-05038-3
UR - https://u-picardie.hal.science/hal-05688256v1
AB - Background: Barrett's esophagus (BE) is a pre-cancerous condition with an increased risk of esophageal adenocarcinoma (EAC). Current surveillance involves white light endoscopy with random biopsies (Seattle Protocol, SP) but has limitations. This study explores high-resolution virtual chromoendoscopy (HRMC) as a potential alternative. Methods: This controlled trial will enroll 110 patients with Barrett's esophagus (BE) across 15 gastroenterology departments in France. Each patient will undergo both HRMC and SP examinations during the same endoscopic procedure. Although the trial is non-randomized, it is important to highlight that the two endoscopists performing either the HRMC or the SP will be blinded to each other's results. Therefore, each patient will serve as their own control. Biopsy decisions will be based on both methods, with any visible lesions resected. The primary objective is to compare the detection rate of HGD and EAC lesions using HRMC with targeted biopsies versus SP with random biopsies. Secondary objectives include comparing detection rates of LGD lesions, procedure time, missed lesions, and cost-effectiveness. Discussion: If HRMC proves superior to SP for detecting HGD and EAC, it could lead to more accurate, efficient, and cost-effective BE surveillance strategies, improving patient outcomes and resource utilization. Trial registration: ClinicalTrials.gov NCT05229783 - First Submitted 2021-12-07.
SN - 1471-230X
ER -