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PreprintCC BY-NC-NDbioRxiv

Polygenic evolution towards a morning chronotype in modern humans

  • S. Hamamoto
  • Y. Moriya
  • N. T. Fujito
  • S. Higuchi
  • K. M. Teshima
  • T. Hayakawa1
  1. 1Faculty of Arts and Science, Kyushu University
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Abstract

Chronotype is a behavioural phenotype, and its phenotypic trend is considered to change at higher latitudes. In the current study, we performed a polygenic assessment of chronotype trend using associated single nucleotide polymorphisms identified by a genome wide-association study. We found that the phenotypic trend towards morningness increased drastically during the migration of anatomically modern humans above 20 degrees north. Furthermore, two types of latitudinal selection of morningness alleles contributed to establishing the trend towards the morning chronotype at higher latitudes. We propose that the trend towards morningness is stronger in present-day modern humans living above 20 degrees north than in Neanderthals.

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Cite

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BibTeX
@misc{hamamoto2026polygenic,
  title = {{Polygenic evolution towards a morning chronotype in modern humans}},
  author = {S. Hamamoto and Y. Moriya and N. T. Fujito and S. Higuchi and K. M. Teshima and T. Hayakawa},
  howpublished = {bioRxiv},
  year = {2026},
  month = nov,
  doi = {10.64898/2026.11.01.763544},
  url = {https://www.biorxiv.org/content/10.64898/2026.11.01.763544v1},
  note = {CC BY-NC-ND},
}
RIS
TY  - UNPB
TI  - Polygenic evolution towards a morning chronotype in modern humans
AU  - S. Hamamoto
AU  - Y. Moriya
AU  - N. T. Fujito
AU  - S. Higuchi
AU  - K. M. Teshima
AU  - T. Hayakawa
PY  - 2026
DA  - 2026/11/01
PB  - bioRxiv
DO  - 10.64898/2026.11.01.763544
UR  - https://www.biorxiv.org/content/10.64898/2026.11.01.763544v1
AB  - Chronotype is a behavioural phenotype, and its phenotypic trend is considered to change at higher latitudes. In the current study, we performed a polygenic assessment of chronotype trend using associated single nucleotide polymorphisms identified by a genome wide-association study. We found that the phenotypic trend towards morningness increased drastically during the migration of anatomically modern humans above 20 degrees north. Furthermore, two types of latitudinal selection of morningness alleles contributed to establishing the trend towards the morning chronotype at higher latitudes. We propose that the trend towards morningness is stronger in present-day modern humans living above 20 degrees north than in Neanderthals.
ER  -