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PreprintCC BYChemRxiv

Mitigating Catalyst Leaching and Deactivation in Heterogeneous Hydrogen-Bonding/Tertiary Amine Chiral Organocatalysts

  • Adrián López-Francés1
  • Aitor Maestro2,3
  1. 1Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, United Kingdom, OX1 3TA
  2. 2Department of Chemistry, Faculty of Science and Engineering
  3. 3Swansea University
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Abstract

The heterogenisation of chiral organocatalysts remains a key strategy for developing sustainable and recyclable chemical processes. However, long-term stability is often compromised by catalyst leaching and deactivation. In this work, we present a combined computational and experimental study of the deactivation pathways in an ester-linked heterogeneous thiourea/tertiary amine organocatalyst. By identifying the fundamental causes of activity loss, we establish a rational design framework for developing a more robust, high-performance triazole-linked heterogeneous catalyst with extended lifetime and improved reusability.

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Cite

BibTeXRIS
BibTeX
@misc{lopezfrances2026mitigating,
  title = {{Mitigating Catalyst Leaching and Deactivation in Heterogeneous Hydrogen-Bonding/Tertiary Amine Chiral Organocatalysts}},
  author = {Adrián López-Francés and Aitor Maestro},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15007046/v2},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15007046/v2},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Mitigating Catalyst Leaching and Deactivation in Heterogeneous Hydrogen-Bonding/Tertiary Amine Chiral Organocatalysts
AU  - Adrián López-Francés
AU  - Aitor Maestro
PY  - 2026
DA  - 2026/10/28
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15007046/v2
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15007046/v2
AB  - The heterogenisation of chiral organocatalysts remains a key strategy for developing sustainable and recyclable chemical processes. However, long-term stability is often compromised by catalyst leaching and deactivation. In this work, we present a combined computational and experimental study of the deactivation pathways in an ester-linked heterogeneous thiourea/tertiary amine organocatalyst. By identifying the fundamental causes of activity loss, we establish a rational design framework for developing a more robust, high-performance triazole-linked heterogeneous catalyst with extended lifetime and improved reusability.
ER  -