Topological Oncology — Isotopic Fractionation as a Possible Wave-Impedance Shift and Phase-Decoherence Organiser in Malignant Networks
Abstract
Conventional oncology views cancer primarily through the lens of genetic mutations and localized biochemical signalling. Empirical studies have documented systematic isotopic fractionation patterns in many cancerous tissues and biofluids, including carbon-13 enrichment, nitrogen-15 depletion, and copper/zinc isotope shifts. Within standard biochemistry these are treated as metabolic by-products. In this note we examine the same anomalies through the geometric vocabulary of G-MaTT, treating stable-isotope substitutions as possible microscopic mass defects that may shift local wave impedance. When such a shift is pictured as approaching or exceeding the illustrative coherence window W = √α ≈ 0.0854, collective phase synchronisation among cellular oscillators may be disrupted. Cancer is therefore organised, as a working hypothesis, as a possible topological decoherence event — a decoupling of local oscillators from a larger phase-coherent field. A short extension considers whether certain dietary carotenoids could act as low-defect geometric references that modestly stabilise local impedance. The framework is offered strictly as a speculative organising picture; no first-principles derivation of malignant transformation, no quantitative prediction of onset, and no therapeutic claim are made.
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BibTeX
@misc{yeo2026topological,
title = {{Topological Oncology — Isotopic Fractionation as a Possible Wave-Impedance Shift and Phase-Decoherence Organiser in Malignant Networks}},
author = {Soon Hee@Bungsuh Yeo},
howpublished = {Zenodo},
year = {2026},
month = oct,
doi = {10.5281/zenodo.23413508},
url = {https://zenodo.org/records/23413508},
note = {CC BY 4.0},
}
RIS
TY - UNPB
TI - Topological Oncology — Isotopic Fractionation as a Possible Wave-Impedance Shift and Phase-Decoherence Organiser in Malignant Networks
AU - Soon Hee@Bungsuh Yeo
PY - 2026
DA - 2026/10/16
PB - Zenodo
DO - 10.5281/zenodo.23413508
UR - https://zenodo.org/records/23413508
AB - Conventional oncology views cancer primarily through the lens of genetic mutations and localized biochemical signalling. Empirical studies have documented systematic isotopic fractionation patterns in many cancerous tissues and biofluids, including carbon-13 enrichment, nitrogen-15 depletion, and copper/zinc isotope shifts. Within standard biochemistry these are treated as metabolic by-products. In this note we examine the same anomalies through the geometric vocabulary of G-MaTT, treating stable-isotope substitutions as possible microscopic mass defects that may shift local wave impedance. When such a shift is pictured as approaching or exceeding the illustrative coherence window W = √α ≈ 0.0854, collective phase synchronisation among cellular oscillators may be disrupted. Cancer is therefore organised, as a working hypothesis, as a possible topological decoherence event — a decoupling of local oscillators from a larger phase-coherent field. A short extension considers whether certain dietary carotenoids could act as low-defect geometric references that modestly stabilise local impedance. The framework is offered strictly as a speculative organising picture; no first-principles derivation of malignant transformation, no quantitative prediction of onset, and no therapeutic claim are made.
ER -