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Peer-reviewedCC BYRevista da Associacao Medica Brasileira (1992)

The effect of propolis oral care on oral mucositis in intensive care patients with chronic obstructive pulmonary disease: a randomized controlled trial

  • Büşra Nur Özel Akyürek1
  • Sevda Korkut2
  • Mustafa Öner Küçük3
  • Ayşe Işın Gürpınar4
4 affiliations
  1. 1Erciyes University, Institute of Health Sciences, Department of Nursing – Kayseri, Türkiye.
  2. 2Erciyes University, Faculty of Health Sciences, Department of Nursing – Kayseri, Türkiye.
  3. 3Nuh Naci Yazgan University, Faculty of Dentistry, Department of Microbiology – Kayseri, Türkiye.
  4. 4Kayseri State Hospital, Department of Chest Diseases – Kayseri, Türkiye.
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Abstract

SUMMARY: OBJECTIVE:: This study aimed to evaluate the preventive effect of adding a propolis gargle to standard oral care on the development of oral mucositis in critically ill patients with chronic obstructive pulmonary disease.

METHODS:: This randomized controlled trial included 60 critically ill patients with chronic obstructive pulmonary disease. Both groups received the institutional standard oral care protocol with 0.2% chlorhexidine gluconate three times daily. The intervention group additionally received a propolis gargle three times daily for 15 days. Oral mucosal status was evaluated using the total oral mucosa score.

RESULTS:: There was no significant difference in oral mucosa scores between the groups at baseline, whereas oral mucosa scores were significantly lower in the intervention group than in the control group at the 7- and 15-day follow-ups (p<0.001).

CONCLUSION:: Adding propolis gargle to standard oral care significantly reduced the development of oral mucositis in critically ill patients with chronic obstructive pulmonary disease. However, because the intervention group received additional oral care exposure, the independent effect of propolis cannot be determined and requires further investigation.

Clinical Trial Registration Number: ClinicalTrials.gov Identifier: NCT07426198.

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Cite

BibTeXRIS
BibTeX
@article{akyurek2026effect,
  title = {{The effect of propolis oral care on oral mucositis in intensive care patients with chronic obstructive pulmonary disease: a randomized controlled trial}},
  author = {Büşra Nur Özel Akyürek and Sevda Korkut and Mustafa Öner Küçük and Ayşe Işın Gürpınar},
  journal = {Revista da Associacao Medica Brasileira (1992)},
  year = {2026},
  month = oct,
  doi = {10.1590/1806-9282.20260772},
  url = {https://europepmc.org/article/PMC/PMC13722093},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - The effect of propolis oral care on oral mucositis in intensive care patients with chronic obstructive pulmonary disease: a randomized controlled trial
AU  - Büşra Nur Özel Akyürek
AU  - Sevda Korkut
AU  - Mustafa Öner Küçük
AU  - Ayşe Işın Gürpınar
PY  - 2026
DA  - 2026/10/30
JO  - Revista da Associacao Medica Brasileira (1992)
DO  - 10.1590/1806-9282.20260772
UR  - https://europepmc.org/article/PMC/PMC13722093
AB  - SUMMARY: OBJECTIVE:: This study aimed to evaluate the preventive effect of adding a propolis gargle to standard oral care on the development of oral mucositis in critically ill patients with chronic obstructive pulmonary disease.  METHODS:: This randomized controlled trial included 60 critically ill patients with chronic obstructive pulmonary disease. Both groups received the institutional standard oral care protocol with 0.2% chlorhexidine gluconate three times daily. The intervention group additionally received a propolis gargle three times daily for 15 days. Oral mucosal status was evaluated using the total oral mucosa score.  RESULTS:: There was no significant difference in oral mucosa scores between the groups at baseline, whereas oral mucosa scores were significantly lower in the intervention group than in the control group at the 7- and 15-day follow-ups (p<0.001).  CONCLUSION:: Adding propolis gargle to standard oral care significantly reduced the development of oral mucositis in critically ill patients with chronic obstructive pulmonary disease. However, because the intervention group received additional oral care exposure, the independent effect of propolis cannot be determined and requires further investigation.  Clinical Trial Registration Number: ClinicalTrials.gov Identifier: NCT07426198.
SN  - 0104-4230
SN  - 1806-9282
ER  -