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Peer-reviewedCC BYNatural products and bioprospecting

Bioactive components from Sinomenium acutum exhibit anti-inflammatory activity and sensitize cervical cancer cells to paclitaxel.

  • Xilei Wang1,2
  • Chengjing Zhu1,2
  • Xinyu Du1,2
  • Qiang Wang3
  • Jianqing Yu4,5
5 affiliations
  1. 1Department of Pharmacy, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China.
  2. 2Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.
  3. 3College of Pharmacy, South-Central Minzu University, 182 Minzu Road, Wuhan, 430074, China.
  4. 4Department of Pharmacy, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430071, China. [email protected].
  5. 5Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China. [email protected].
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Abstract

Six previously undescribed compounds, together with twelve known compounds, were isolated from Sinomenium acutum. The structures of the unreported compounds were determined by comprehensive spectroscopic data analysis, ¹³C NMR calculations followed by DP4 + analysis, ECD calculations, and single-crystal X-ray diffraction analysis. Nine compounds exhibited more potent anti-inflammatory activities than the positive control indomethacin. The structure-activity relationship of the isolates with anti-inflammatory effects was elucidated, providing some useful clues for designing and developing structurally novel anti-inflammatory drugs. Furthermore, five compounds reversed the paclitaxel resistance in paclitaxel-resistant cervical cancer cells HeLa/PTX. The combination of compound 4 and paclitaxel promoted cancer cell apoptosis.

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Cite

BibTeXRIS
BibTeX
@article{wang2026bioactive,
  title = {{Bioactive components from Sinomenium acutum exhibit anti-inflammatory activity and sensitize cervical cancer cells to paclitaxel.}},
  author = {Xilei Wang and Chengjing Zhu and Xinyu Du and Qiang Wang and Jianqing Yu},
  journal = {Natural products and bioprospecting},
  year = {2026},
  month = oct,
  doi = {10.1007/s13659-026-00652-w},
  url = {https://europepmc.org/article/MED/42895598},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Bioactive components from Sinomenium acutum exhibit anti-inflammatory activity and sensitize cervical cancer cells to paclitaxel.
AU  - Xilei Wang
AU  - Chengjing Zhu
AU  - Xinyu Du
AU  - Qiang Wang
AU  - Jianqing Yu
PY  - 2026
DA  - 2026/10/19
JO  - Natural products and bioprospecting
DO  - 10.1007/s13659-026-00652-w
UR  - https://europepmc.org/article/MED/42895598
AB  - Six previously undescribed compounds, together with twelve known compounds, were isolated from Sinomenium acutum. The structures of the unreported compounds were determined by comprehensive spectroscopic data analysis, ¹³C NMR calculations followed by DP4 + analysis, ECD calculations, and single-crystal X-ray diffraction analysis. Nine compounds exhibited more potent anti-inflammatory activities than the positive control indomethacin. The structure-activity relationship of the isolates with anti-inflammatory effects was elucidated, providing some useful clues for designing and developing structurally novel anti-inflammatory drugs. Furthermore, five compounds reversed the paclitaxel resistance in paclitaxel-resistant cervical cancer cells HeLa/PTX. The combination of compound 4 and paclitaxel promoted cancer cell apoptosis.
SN  - 2192-2195
SN  - 2192-2209
ER  -