Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 7 min ago
Peer-reviewedCC BYClinical and Translational Discovery

Advances in CRISPR‐based detection technologies for severe fever with thrombocytopenia syndrome virus (Dabiebanda virus): A mini review

  • Junhu Wang1
  • Changqiang Zhu1
  • Jinzhao Chu2
  • Yingqing Mao1
  • Yixin Ge1
  • Haiming Yi1
  • Hongming Wang1
  • Yuexi Li1
  • Yong Qi1
  1. 1Huadong Research Institute for Medicine and Biotechniques Nanjing Jiangsu Province China
  2. 2Department of Military Preventive MedicineThird Military Medical University (Army Medical University)Chongqing China
Read full textPDFDOICite

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is an acute infectious disease caused by the Dabiebanda virus, also referred to as the SFTS virus (SFTSV). Primarily transmitted via tick bites, SFTS occurs sporadically in East Asia and poses a serious threat to human health, with a reported mortality rate of up to 30%. In 2018, the World Health Organization designated SFTSV infection as a priority disease requiring urgent research and therapeutic development. In recent years, the prevalence range of this virus has shown a tendency to expand gradually. Rapid, sensitive, and specific detection of SFTSV is therefore essential for effective disease prevention and control. The CRISPR‐Cas system has emerged as a promising molecular diagnostic technology. By employing specifically designed guide RNAs (such as sgRNA or crRNA) to direct Cas proteins for targeted nucleic acid recognition and cleavage, it offers superior sensitivity and specificity compared to conventional detection methods. This approach has been increasingly applied in SFTS diagnosis. Despite its significant advantages over traditional techniques, challenges remain in terms of technical stability, cost‐effectiveness, and integration with existing diagnostic platforms. This mini review highlights recent advances in CRISPR‐based detection of SFTSV and discusses its potential to enable rapid diagnosis and support precise disease management.

Related

  1. Blood-Based Biomarkers in Alzheimer's Disease: Advances in Detection Technologies and Clinical Applications.
    Shuangshuang Li, Lin Huang, Qihao Guo
    Aging medicine (Milton (N.S.W))Peer-reviewedCC BY-NCFull textPsychiatry & mental healthEurope PMCPMC
  2. Editorial: Advances and challenges in orbital imaging: from radiography to modern MRI and 3D technologies
    Alon Kahana, Alon Kahana
    Frontiers in OphthalmologyPeer-reviewedCC BYFull textGeneral medicineDOAJ
  3. Advances in Diagnostic Testing for Eosinophilic Esophagitis: Current Approaches, Limitations, and Emerging Technologies
    Maanasa Naga Laxmi Pulavarty, Amy Meehan, Cary Qualia
    Diagnostics (Basel, Switzerland)Peer-reviewedCC BYFull textGeneral medicineEurope PMC
  4. Molecular evidence suggestive of transovarial transmission of severe fever with thrombocytopenia syndrome virus in chigger mites
    Hyeon Seung Lee, Seong Yoon Kim, Hyunwoo Kim +2
    Scientific ReportsPeer-reviewedCC BY 4.0Full textInfectious diseaseCrossref
  5. Utilising digital technologies for mycetoma management: A comprehensive review of advances and opportunities
    Ahmad Mohammad Al Zamel, Ali Awadallah Saeed, Malaz Abdelrahman Ahmed +4
    PLOS Digital HealthPeer-reviewedCC BY 4.0Full textMedicinal chemistry & drug discoveryInfectious diseasePLOS

Cite

BibTeXRIS
BibTeX
@article{wang2026advances,
  title = {{Advances in CRISPR‐based detection technologies for severe fever with thrombocytopenia syndrome virus (Dabiebanda virus): A mini review}},
  author = {Junhu Wang and Changqiang Zhu and Jinzhao Chu and Yingqing Mao and Yixin Ge and Haiming Yi and Hongming Wang and Yuexi Li and Yong Qi},
  journal = {Clinical and Translational Discovery},
  year = {2026},
  month = oct,
  doi = {10.1002/ctd2.70216},
  url = {https://doi.org/10.1002/ctd2.70216},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Advances in CRISPR‐based detection technologies for severe fever with thrombocytopenia syndrome virus (Dabiebanda virus): A mini review
AU  - Junhu Wang
AU  - Changqiang Zhu
AU  - Jinzhao Chu
AU  - Yingqing Mao
AU  - Yixin Ge
AU  - Haiming Yi
AU  - Hongming Wang
AU  - Yuexi Li
AU  - Yong Qi
PY  - 2026
DA  - 2026/10/26
JO  - Clinical and Translational Discovery
DO  - 10.1002/ctd2.70216
UR  - https://doi.org/10.1002/ctd2.70216
AB  - Severe fever with thrombocytopenia syndrome (SFTS) is an acute infectious disease caused by the Dabiebanda virus, also referred to as the SFTS virus (SFTSV). Primarily transmitted via tick bites, SFTS occurs sporadically in East Asia and poses a serious threat to human health, with a reported mortality rate of up to 30%. In 2018, the World Health Organization designated SFTSV infection as a priority disease requiring urgent research and therapeutic development. In recent years, the prevalence range of this virus has shown a tendency to expand gradually. Rapid, sensitive, and specific detection of SFTSV is therefore essential for effective disease prevention and control. The CRISPR‐Cas system has emerged as a promising molecular diagnostic technology. By employing specifically designed guide RNAs (such as sgRNA or crRNA) to direct Cas proteins for targeted nucleic acid recognition and cleavage, it offers superior sensitivity and specificity compared to conventional detection methods. This approach has been increasingly applied in SFTS diagnosis. Despite its significant advantages over traditional techniques, challenges remain in terms of technical stability, cost‐effectiveness, and integration with existing diagnostic platforms. This mini review highlights recent advances in CRISPR‐based detection of SFTSV and discusses its potential to enable rapid diagnosis and support precise disease management.
SN  - 2768-0622
ER  -