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Peer-reviewedCC BYCell death discovery

The landscape and plasticity of transposable element expression in an adult stem cell of high physiological and clinical significance.

  • Xingyu Fu1,2,3,4,5
  • Qiangwei Cai1,3,5
  • Jingjing Zhao1,5
  • Ying Chen1,2,3,5
  • Jiangping He6
  • Ke Hu1,2,3,4,5
  • Yi Yin1,2,3,4,5
  • Wenhan Yang7
  • Lian Wang7
  • Jiayi Zhao5
  • Shuo Wu1
  • Fei He3
7 more authors
  • Zhenzhou Li2
  • Jiekai Chen8
  • Keqiang Zuo3
  • Xianghuai Xu9
  • Huan Wang10
  • Peibin Dai11,12,13
  • Zhengliang Gao14,15
15 affiliations
  1. 1Shanghai Baoshan Luodian Hospital, School of Medicine, Shanghai University, Shanghai, 201908, China.
  2. 2Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University, Ningxia, 750004, China.
  3. 3Department of Cardiac and Vascular Surgery, Huaihe Hospital of Henan University, 115 Ximen Street, Kaifeng, Henan, 475000, China.
  4. 4Department of Anesthesiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, 200135, China.
  5. 5Department of General Practice, Shanghai 411 Hospital, China RongTong Medical Healthcare Group Co., Ltd., Shanghai, 200081, China.
  6. 6Guangzhou National Laboratory, Guangzhou, 510530, China.
  7. 7Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China.
  8. 8Center for Biomedical Digital Science, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  9. 9Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China. [email protected].
  10. 10Department of Anesthesiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, 200135, China. [email protected].
  11. 11Shanghai Baoshan Luodian Hospital, School of Medicine, Shanghai University, Shanghai, 201908, China. [email protected].
  12. 12Department of Anesthesiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, 200135, China. [email protected].
  13. 13Department of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China. [email protected].
  14. 14Department of Anesthesiology, Gongli Hospital of Shanghai Pudong New Area, Shanghai, 200135, China. [email protected].
  15. 15China-Japan Friendship Medical Research Institute, School of Medicine, Shanghai University, Shanghai, 200444, China. [email protected].
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Abstract

Transposable elements (TEs) contribute to diverse aspects of stem cell biology, particularly in germline and pluripotent stem cells, which typically exhibit more open chromatin. In human adult stem cells (ASCs), however, a comprehensive framework describing the landscape and plasticity of TE expression and how these patterns may inform studies of ASC biological properties and considerations relevant to clinical translations has been lacking. Here, using human adipose-derived mesenchymal stem cells (hADSCs) as an adult stem cell paradigm, we combined transcriptomic profiling with integrative bioinformatics to map the TE expression landscape in hADSCs across multiple biologically and manufacturing-relevant contexts. We examined TE expression dynamics across culture conditions, senescence, and donor-related backgrounds, and found that TE expression patterns in hADSCs were highly plastic in response to environmental cues. Comparative analyses of TE and gene expression showed that TE patterns and dynamics correlated with transcriptomic signatures related to mesenchymal stem/stromal cells (MSCs) biological states. HERV16-int, L1MEh, and MER61E emerged as recurrent, context-responsive TE candidates associated with transcriptional signatures related to MSC immune-related, stemness-related, and senescence-related programs. This work addresses a gap in MSC TE expression profiling and provides a framework for prioritizing candidate TE-expression features with potential relevance to future MSC manufacturing and quality-assessment studies, pending orthogonal and functional validation.

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Cite

BibTeXRIS
BibTeX
@article{fu2026landscape,
  title = {{The landscape and plasticity of transposable element expression in an adult stem cell of high physiological and clinical significance.}},
  author = {Xingyu Fu and Qiangwei Cai and Jingjing Zhao and Ying Chen and Jiangping He and Ke Hu and Yi Yin and Wenhan Yang and Lian Wang and Jiayi Zhao and Shuo Wu and Fei He and Zhenzhou Li and Jiekai Chen and Keqiang Zuo and Xianghuai Xu and Huan Wang and Peibin Dai and Zhengliang Gao},
  journal = {Cell death discovery},
  year = {2026},
  month = aug,
  doi = {10.1038/s41420-026-03277-7},
  url = {https://europepmc.org/article/MED/42957621},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - The landscape and plasticity of transposable element expression in an adult stem cell of high physiological and clinical significance.
AU  - Xingyu Fu
AU  - Qiangwei Cai
AU  - Jingjing Zhao
AU  - Ying Chen
AU  - Jiangping He
AU  - Ke Hu
AU  - Yi Yin
AU  - Wenhan Yang
AU  - Lian Wang
AU  - Jiayi Zhao
AU  - Shuo Wu
AU  - Fei He
AU  - Zhenzhou Li
AU  - Jiekai Chen
AU  - Keqiang Zuo
AU  - Xianghuai Xu
AU  - Huan Wang
AU  - Peibin Dai
AU  - Zhengliang Gao
PY  - 2026
DA  - 2026/08/04
JO  - Cell death discovery
DO  - 10.1038/s41420-026-03277-7
UR  - https://europepmc.org/article/MED/42957621
AB  - Transposable elements (TEs) contribute to diverse aspects of stem cell biology, particularly in germline and pluripotent stem cells, which typically exhibit more open chromatin. In human adult stem cells (ASCs), however, a comprehensive framework describing the landscape and plasticity of TE expression and how these patterns may inform studies of ASC biological properties and considerations relevant to clinical translations has been lacking. Here, using human adipose-derived mesenchymal stem cells (hADSCs) as an adult stem cell paradigm, we combined transcriptomic profiling with integrative bioinformatics to map the TE expression landscape in hADSCs across multiple biologically and manufacturing-relevant contexts. We examined TE expression dynamics across culture conditions, senescence, and donor-related backgrounds, and found that TE expression patterns in hADSCs were highly plastic in response to environmental cues. Comparative analyses of TE and gene expression showed that TE patterns and dynamics correlated with transcriptomic signatures related to mesenchymal stem/stromal cells (MSCs) biological states. HERV16-int, L1MEh, and MER61E emerged as recurrent, context-responsive TE candidates associated with transcriptional signatures related to MSC immune-related, stemness-related, and senescence-related programs. This work addresses a gap in MSC TE expression profiling and provides a framework for prioritizing candidate TE-expression features with potential relevance to future MSC manufacturing and quality-assessment studies, pending orthogonal and functional validation.
SN  - 2058-7716
ER  -