Metabolic risk factors for fungal ball sinusitis in perimenopausal women
- 1Department of Otolaryngology-Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University , , ,
- 2Metabolic Vascular Diseases Key Laboratory of Sichuan Province, and Metabolic Vascular Diseases Key Laboratory of Sichuan-Chongqing Cooperation , , ,
- 3Department of Pathogen Biology, School of Basic Medicine, Southwest Medical University , , ,
Abstract
Objectives: Rising incidence of fungal ball sinusitis (FBS) is frequently observed in perimenopausal women. This study aimed to explore the relationships between TyG-BMI, HDL-C and FBS in this specific population.
Study design: This single-center retrospective study enrolled FBS patients from 2015 to 2025. Perimenopausal women aged 45–60 years were selected as the study subjects, and patients with chronic non-fungal sinusitis (CNFS) were selected as the control group. Biochemical indicators were compared, and participants were stratified by TyG-BMI quartiles. Logistic regression was used to identify independent risk factors, and ROC curves were applied to assess predictive efficiency.
Results: The cases of FBS showed an increasing trend. The patients were predominantly middle-aged and elderly individuals, and the proportion of female patients was significantly higher than that of males (63.96% vs. 36.04%), with the peak age of female morbidity concentrated between 45 and 60 years. Intergroup comparison demonstrated that the FBS group had significantly lower HDL-C levels and significantly higher TyG and TyG-BMI values than the CNFS group. With the elevation of TyG-BMI quartiles, the HDL-C level decreased progressively, accompanied by a significantly rising trend in the prevalence of FBS (P < 0.05). Logistic regression analysis confirmed that HDL-C and quartile of TyG-BMI were independent influence factors for FBS in perimenopausal women (P = 0.008, OR = 0.482,95%CI:0.282–0.823; P = 0.04, OR = 1.192, 95%CI:1.008–1.409; respectively). ROC analysis revealed that the combined model of TyG-BMI and HDL-C exhibited limited predictive value for FBS.
Conclusion: The incidence of FBS has been increasing annually, especially in perimenopausal women. Decreased HDL-C and elevated TyG-BMI are independent metabolic risk factors for FBS in perimenopausal women. Targeted metabolic monitoring and early intervention may be associated with lower FBS risk.
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BibTeX
@article{wang2026metabolic,
title = {{Metabolic risk factors for fungal ball sinusitis in perimenopausal women}},
author = {Shi-Yun Wang and Wei Xu and Yue-Xi Liu and Liang Jiang and Yong Xu and Fang-Yuan Teng and Xiao-Yan Hu and Hong-Xia Li},
journal = {Frontiers in allergy},
year = {2026},
month = oct,
doi = {10.3389/falgy.2026.1900638},
url = {https://europepmc.org/article/PMC/PMC13724466},
note = {CC BY},
}
RIS
TY - JOUR
TI - Metabolic risk factors for fungal ball sinusitis in perimenopausal women
AU - Shi-Yun Wang
AU - Wei Xu
AU - Yue-Xi Liu
AU - Liang Jiang
AU - Yong Xu
AU - Fang-Yuan Teng
AU - Xiao-Yan Hu
AU - Hong-Xia Li
PY - 2026
DA - 2026/10/19
JO - Frontiers in allergy
DO - 10.3389/falgy.2026.1900638
UR - https://europepmc.org/article/PMC/PMC13724466
AB - Objectives: Rising incidence of fungal ball sinusitis (FBS) is frequently observed in perimenopausal women. This study aimed to explore the relationships between TyG-BMI, HDL-C and FBS in this specific population. Study design: This single-center retrospective study enrolled FBS patients from 2015 to 2025. Perimenopausal women aged 45–60 years were selected as the study subjects, and patients with chronic non-fungal sinusitis (CNFS) were selected as the control group. Biochemical indicators were compared, and participants were stratified by TyG-BMI quartiles. Logistic regression was used to identify independent risk factors, and ROC curves were applied to assess predictive efficiency. Results: The cases of FBS showed an increasing trend. The patients were predominantly middle-aged and elderly individuals, and the proportion of female patients was significantly higher than that of males (63.96% vs. 36.04%), with the peak age of female morbidity concentrated between 45 and 60 years. Intergroup comparison demonstrated that the FBS group had significantly lower HDL-C levels and significantly higher TyG and TyG-BMI values than the CNFS group. With the elevation of TyG-BMI quartiles, the HDL-C level decreased progressively, accompanied by a significantly rising trend in the prevalence of FBS (P < 0.05). Logistic regression analysis confirmed that HDL-C and quartile of TyG-BMI were independent influence factors for FBS in perimenopausal women (P = 0.008, OR = 0.482,95%CI:0.282–0.823; P = 0.04, OR = 1.192, 95%CI:1.008–1.409; respectively). ROC analysis revealed that the combined model of TyG-BMI and HDL-C exhibited limited predictive value for FBS. Conclusion: The incidence of FBS has been increasing annually, especially in perimenopausal women. Decreased HDL-C and elevated TyG-BMI are independent metabolic risk factors for FBS in perimenopausal women. Targeted metabolic monitoring and early intervention may be associated with lower FBS risk.
SN - 2673-6101
ER -