Zeta potential and endothelialization of implant materials
- 1Institute for ImplantatTechnology and Biomaterials e.V., Friedrich-Barnewitz- Strasse 4, 18119 Rostock-Warnemünde, Germany
- 2ImplantatTechnology and Biomaterials e.V., 18119 Rostock-Warnemünde, Germany
- 3Institute for Biomedical Engineering, Rostock University Medical Center, Rostock-Warnemünde, Germany
Abstract
Surface charge is considered a key factor influencing cell-material interactions and may affect the endothelialization of cardiovascular implant materials. In this study, the zeta potentials of aliphatic polyesters, polyurethanes, and expanded polytetrafluoroethylene (ePTFE) were determined before and after exposure to serum. While the investigated materials exhibited strongly different negative zeta potential values prior to serum treatment, these differences largely diminished following serum incubation, indicating a pronounced masking effect due to adsorption of serum-derived biomolecules. Endothelialization was assessed by fluorescence microscopic analysis of the endothelial cell cytoskeleton, revealing no clear relationship between the initial surface charge and cell adhesion or spreading behavior. Overall, the results suggest that native zeta potential has no or only a minor influence on endothelialization under biologically relevant conditions. Therefore, zeta potential alone is not sufficient to predict the endothelialization potential of implant materials, emphasizing the importance of considering protein conditioning effects and additional surface characteristics.
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BibTeX
@article{valeria2026zeta,
title = {{Zeta potential and endothelialization of implant materials}},
author = {Khaimov Valeria and Schaperjahn Birthe and Reske Thomas and Koper Daniela and Merryweather Bradley and Grabow Niels and Schmitz Klaus-Peter and Siewert Stefan},
journal = {Current Directions in Biomedical Engineering},
year = {2026},
month = oct,
doi = {10.1515/cdbme-2026-0163},
url = {https://doi.org/10.1515/cdbme-2026-0163},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Zeta potential and endothelialization of implant materials
AU - Khaimov Valeria
AU - Schaperjahn Birthe
AU - Reske Thomas
AU - Koper Daniela
AU - Merryweather Bradley
AU - Grabow Niels
AU - Schmitz Klaus-Peter
AU - Siewert Stefan
PY - 2026
DA - 2026/10/26
JO - Current Directions in Biomedical Engineering
DO - 10.1515/cdbme-2026-0163
UR - https://doi.org/10.1515/cdbme-2026-0163
AB - Surface charge is considered a key factor influencing cell-material interactions and may affect the endothelialization of cardiovascular implant materials. In this study, the zeta potentials of aliphatic polyesters, polyurethanes, and expanded polytetrafluoroethylene (ePTFE) were determined before and after exposure to serum. While the investigated materials exhibited strongly different negative zeta potential values prior to serum treatment, these differences largely diminished following serum incubation, indicating a pronounced masking effect due to adsorption of serum-derived biomolecules. Endothelialization was assessed by fluorescence microscopic analysis of the endothelial cell cytoskeleton, revealing no clear relationship between the initial surface charge and cell adhesion or spreading behavior. Overall, the results suggest that native zeta potential has no or only a minor influence on endothelialization under biologically relevant conditions. Therefore, zeta potential alone is not sufficient to predict the endothelialization potential of implant materials, emphasizing the importance of considering protein conditioning effects and additional surface characteristics.
SN - 2364-5504
ER -