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Peer-reviewedCC BY 4.0Frontiers in Pharmacology

Multi-target effects and clinical optimization treatment strategies of recombinant human B-type natriuretic peptide in acute heart failure and myocardial infarction

  • Yaling Zhou1
  • Qiliang Hou2
  • Yi Yang1
  • Mengxiang Zhang1
  • Zhongmou Zhang1
  • Zhimin Dou1,2
  • Bin Li1,2
  1. 1The First School of Clinical Medicine, Lanzhou University and The First Hospital of Lanzhou University
  2. 2Department of Critical Care Medicine, The First Hospital of Lanzhou University
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Abstract

Acute cardiovascular diseases have become a serious public health challenge worldwide. Optimizing treatment strategies is crucial for improving the prognosis of patients. Recombinant human B-type natriuretic peptide (rhBNP) has garnered significant attention due to its multi-target mechanisms of action. This article aims to comprehensively review the multi-target effects of rhBNP in the treatment of acute cardiovascular diseases, and briefly explain its molecular mechanism through the activation of natriuretic peptide receptors and multiple downstream signaling pathways. In addition, combined with the latest clinical evidence, the optimization strategies for the clinical application of rhBNP are deeply discussed. However, it is important to acknowledge that current clinical evidence regarding renal protection and long-term clinical outcomes remains mixed. This review aims to provide evidence-based, individualized treatment recommendations for clinical practice, thereby improving the clinical outcomes of patients with acute cardiovascular diseases.

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Cite

BibTeXRIS
BibTeX
@article{zhou2026multitarget,
  title = {{Multi-target effects and clinical optimization treatment strategies of recombinant human B-type natriuretic peptide in acute heart failure and myocardial infarction}},
  author = {Yaling Zhou and Qiliang Hou and Yi Yang and Mengxiang Zhang and Zhongmou Zhang and Zhimin Dou and Bin Li},
  journal = {Frontiers in Pharmacology},
  year = {2026},
  month = oct,
  doi = {10.3389/fphar.2026.1948386},
  url = {https://www.frontiersin.org/articles/10.3389/fphar.2026.1948386/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Multi-target effects and clinical optimization treatment strategies of recombinant human B-type natriuretic peptide in acute heart failure and myocardial infarction
AU  - Yaling Zhou
AU  - Qiliang Hou
AU  - Yi Yang
AU  - Mengxiang Zhang
AU  - Zhongmou Zhang
AU  - Zhimin Dou
AU  - Bin Li
PY  - 2026
DA  - 2026/10/21
JO  - Frontiers in Pharmacology
DO  - 10.3389/fphar.2026.1948386
UR  - https://www.frontiersin.org/articles/10.3389/fphar.2026.1948386/full
AB  - Acute cardiovascular diseases have become a serious public health challenge worldwide. Optimizing treatment strategies is crucial for improving the prognosis of patients. Recombinant human B-type natriuretic peptide (rhBNP) has garnered significant attention due to its multi-target mechanisms of action. This article aims to comprehensively review the multi-target effects of rhBNP in the treatment of acute cardiovascular diseases, and briefly explain its molecular mechanism through the activation of natriuretic peptide receptors and multiple downstream signaling pathways. In addition, combined with the latest clinical evidence, the optimization strategies for the clinical application of rhBNP are deeply discussed. However, it is important to acknowledge that current clinical evidence regarding renal protection and long-term clinical outcomes remains mixed. This review aims to provide evidence-based, individualized treatment recommendations for clinical practice, thereby improving the clinical outcomes of patients with acute cardiovascular diseases.
SN  - 1663-9812
ER  -